Registration Dossier
Registration Dossier
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EC number: 204-234-6 | CAS number: 118-10-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
According to the study report the degradation of cinchonine hydrochloride was between 72.0 and 96.9% within 29 days (after acidification). Cinchonine hydrochloride reached the criteria for ready biodegradability (60% ThCO2 and 10-d window). Therefore, we can conclude that cinchonine is readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The read across substance cinchonine hydrochloride was tested in a CO2 Evolution Test according to the OECD Guideline 301 B for 28 days (and 29 days after acidification) to determine whether the test substance is readily biodegradable. This study showa high variation in the degradation behaviour which is determined by different end of the lag phase in the different replicate vessels with cinchonine hydrochloride. In vessel 7 the lag phase ended between day 4 and 7, in vessel 8 the lag phase ended between day 7 and 11, while in vessel 9 the lag phase continued over 14 days. On day 28 (after acidification) the degradation in vessel 7 and 8 reached extents between 94.9 and 96.9%. Because of the long lag phase the degradation extent in vessel 9 didn’t reached the plateau and was significant lower (72.0%) at the end of the test. The criterion of the difference of extremes of replicate values at the end of the test was therefore fulfilled in two of three test vessels. Because of the differing lag phases the 10-d-window was evaluated separately. The 10-d window was reached in all three test vessels. In vessel 7 and 8 the degradation extents were already on day 11 above 60%. For finding the exact position of the 10-d-window for the degradation in vessel 9 we had to interpolate the degradation extent between the days 14 and 28. The first day with a degradation extent of ≥10% was day 16. On day 26 the degradation extent was 61.9%. Therefore, the pass level for ready biodegradation (60% ThCO2 within a 10-d window) was reached in all three test item replicates and cinchonine can be considered as readily biodegradable.
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