GOLDEN YELLOW SCJ 1006

Endpoint summary

Additional information

Study reports have been available for acute tests with fish, invertebrate, algae, micro-organism and Daphnia reproduction test. The results are summarized as below:

The acute toxicity of the test substance FAT 40'543/A to zebra-fish was determined in a 96-hour static test according to OECD Guideline No. 203 in compliance with Good Laboratory Practice Regulations. A test well above the limit of water solubility was performed and the NOEC was 92.9 mg/L (maximum concentration measured in test) respectively 0.38 mg/L based on maximum water solubility in distilled water and consequently the LC50 is accordingly > 92.9 mg/L respectively >0.38 mg/L. Thus, FAT40543/A had no toxic effects towards zebra-fish within limits of its solubility.

The acute toxicity of the test substance FAT 40'543/A to Daphnia magna was determined in a 48-hour static test according to OECD Guideline No. 202 in compliance with Good Laboratory Practice Regulations. The nominal concentrations tested were 45, 100 and 220 mg test substance/L, and in parallel a control. No effects were noted towards daphnia and thus the 48-hour NOEC (highest concentration without toxic effects) was set to 220 mg/L nominal (31.6 mg/L measured) and therefore is well above the limit of water solubility of FAT40543/A (0.38 mg/L).

The influence of the test substance FAT 40'543/A on the growth of the green algal species Scenedesmus subspicatus was investigated in a 72-hour static test according to OECD Guideline No. 201. This algae test performed using a saturated solution of the test substance (0.27 mg/L) also showed no effect of FAT 40'543/A on growth rate ort biomass. Thus, toxicity to scenedesmus subspicatus can be excluded and the NOEC in this study was set to 0.27 mg/L.

The inhibitory effect of FAT 40'543/A on aerobic waste water bacteria of activated sludge was investigated in a respiration test. The respiration rate of aerobic waste water bacteria was not inhibited when exposed to the test article concentrations in the range from 10 to 320 mg/l. The EC50 (3h) was therefore determined to be >320 mg/l and the NOEC was set to the highest tested concentration of 320 mg/L.

The influence of the test substance FAT 40'543/A on the reproduction and survival rate of Daphnia magna was investigated in a 21 days semi-static test following the OECD Guideline No. 211(draft). The 21-day NOEC and EC50-values for parental mortality and the reproduction rate of the test animals were set to the highest concentration tested in this study in lack of mortality or reproductive effects by the test substance. The 21-day NOEC was therefore set to 0.1 mg/L (highest concentration tested) for parental toxicity and reproductive performance.

In conclusion, no signs of toxicity were seen in all acute and chronic studies performed.

Data on marine species are not available.