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Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

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Administrative data

Endpoint:
toxicity to soil macroorganisms except arthropods: long-term
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The target lipid model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. The TLM, and HC5, have been applied to soils and sediment using equilibrium partitioning (EqP) model. This framework utilizes organic carbon partition coefficients (Koc) to convert aquatic based effect levels (CW) to bulk soil- and sediment-based effect levels. The combined TLM-EqP framework was validated previously for soil and sediment acute and chronic toxicity endpoints. The registered substance is within the scope of the TLM and EqP frameworks.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Refinement and validation of TLM-derived HC5 values. Independent review.
Author:
McGrath JA, Di Toro DM, Fanelli CJ
Year:
2015
Bibliographic source:
HDR, Mahwah, NJ
Reference Type:
publication
Title:
Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments
Author:
Redman AD, Parkerton TF, Paumen ML, McGrath JA, den Haan K, DiToro DM
Year:
2014
Bibliographic source:
Environmental Toxicology and Chemistry, 33: 12, pp. 2679-2687.

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
The target lipid model (McGrath et el., 2015) and equilibrium partitioning model (Redman et al., 2014) as described in the cited references were used to determine soil effect levels of the registered substance.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzene
EC Number:
200-753-7
EC Name:
Benzene
Cas Number:
71-43-2
Molecular formula:
C6H6
IUPAC Name:
benzene
Test material form:
not specified
Details on test material:
Common name: Benzene
No other data provided
Specific details on test material used for the study:
NA

Test organisms

Test organisms (species):
Eisenia fetida
Animal group:
annelids

Results and discussion

Effect concentrationsopen allclose all
Duration:
28 d
Dose descriptor:
LC50
Effect conc.:
52.064 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
56 d
Dose descriptor:
EC10
Effect conc.:
9.974 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The TLM-EqP predicted effect values for Benzene were 52.064 and 49.974 mg/kg soil dw for short-term (28-day LC50) and long-term effects (56-day EC10), respectively.
Executive summary:

The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted effect values for Benzene were 52.064 and 49.974 mg/kg soil dw for short-term (28-day LC50) and long-term effects (56-day EC10), respectively.