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EC number: 200-753-7
CAS number: 71-43-2
ORTHOQUINONE ADDUCT FORMATION
CAT-4-N7Gua (2.3 pmol/10^6 cells) and CAT-4-N3Ade adducts (0.6 pmol/10^6
cells) were detected when MNCs were treated with 75 uM benzene
effect of benzene ortho-quinone (0-150 uM) on cell proliferation and DNA
adducts formation in human mononuclear cells was investigated in vitro.
Cell proliferation was significantly increased following 7, 14 or 21 d
treatment although the extent of stimulation decreased with time. Both
Catechol-4-N7Gua and catechol-4-N3Ade adducts were detected in cells
exposed to 75 uM benzene ortho-quinone. The authors suggest that DNA
damage induced by benzene ortho-quinone may promote growth of human
blood mononuclear cells.
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