Registration Dossier

Administrative data

Description of key information

The key skin and eye irritation studies (BSL Bioservice, 2000a and BSL Bioservice, 2001b) were conducted in accordance with OECD 404 and 405 respectively, and in compliance with GLP. Triethoxy(2,4,4-trimethylpentyl)silane did not meet the EU criteria for classification as irritating to skin or eyes. Minor, reversible effects were observed in both studies.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The key skin and eye irritation studies are the only available data for these endpoints. Both studies are reliable, guideline studies, conducted in accordance with GLP.

No data are available for respiratory irritation.

Justification for classification or non-classification

Based on the available in vivo skin and eye irritation studies, triethoxy (2,4,4 -trimethylpentyl)silane is not classified as irritant according to Regulation (EC) No. 1272/2008.