Registration Dossier
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EC number: 252-558-1 | CAS number: 35435-21-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A 48-h EL50 of <100 mg/l (highest concentration tested, with filtering of the test substance) has been determined for the effects of the test substance on mortality of Daphnia magna based on nominal concentrations, in accordance with test guideline OECD 202. In a parallel test, a 48 hr EL50 of 12 mg/l and a NOEC of 3.2 mg/l (without filtering of the test substance) have been determined for the effects of the test substance on mortality of Daphnia magna based on nominal concentrations and in accordance with test guideline OECD 202.
Key value for chemical safety assessment
Additional information
A 48-h EL50 of <100 mg/l has been determined for effects of the test substance based on mortality of Daphnia magna.
The organisms were exposed to a filtered suspension of the test substance prepared at a loading rate of 100 mg/l. The test result is considered to be reliable. Exposure to unfiltered test medium gave a 48-h EL50 of 12 mg/l and a NOELR of 3.2 mg/l. The loading rates used were all above the water solubility of the substance (<0.1 mg/l). Results of a related study conducted under the same project number, with exposure to a 100 mg/l test medium that had been filtered, gave a similar result to that reported in this study (48-h EL50 <100 mg/l).
Based on the hydrolysis half-life of the test substance (43 hours at pH 7 and 20-25°C, predicted), it is likely that in the absence of undissolved material the organisms would be mainly exposed to a mixture of the parent and the hydrolysis products. Undissolved material might have been present in the test solutions as film on the surface or as hydrolysis resistant micelles of the parent substance and oligomers in the water body. The observations during the tests with fish, daphnia and algae indicate that the dosage of the test item and the filtration step are hypersensitive parameters for the occurrence of undissolved material. A filter is not able to retain effectively undissolved monomers and oligomers.
The results are supported by a reliable study with the read-across substance triethoxyoctylsilane (CAS 2943-75-1). The test substance did not achieve any toxicity when tested at the solubility limit of the substance i.e. the EC50 value was >0.13 mg a.i./l and the NOEC value was ≥0.13 mg a.i./l (nominal concentration). Based on the hydrolysis half-life of the test substance (30-h, predicted), it is likely that the organisms were exposed to a mixture of the parent and hydrolysis products.
Refer to the discussion in the Section 6 endpoint summary (Section 7.0 of CSR) for further discussion of the approach to chemical safety assessment for this registration substance, and justification for read-across used.
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