Registration Dossier
Registration Dossier
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EC number: 203-615-4 | CAS number: 108-78-1
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Scientific publication, the reliability can not be judged. A new test system for predicting carcinogenicity.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- In vitro determination of carcinogenicity of sixty-four compounds using a bovine papilloma virus DNA-carrying C3H/10T(1/2) cell line.
- Author:
- Kowalski LA et al.
- Year:
- 2 000
- Bibliographic source:
- Environ. Mol. Mutagen. Vol. 35(4), 300-311
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
- Type of study / information:
- In vitro test for predicting rodent carcinogenicity
- Principles of method if other than guideline:
- A new test system for predicting carcinogenicity was tested with 64 chemicals.
Test material
- Reference substance name:
- Melamine
- EC Number:
- 203-615-4
- EC Name:
- Melamine
- Cas Number:
- 108-78-1
- Molecular formula:
- C3H6N6
- IUPAC Name:
- 1,3,5-triazine-2,4,6-triamine
- Details on test material:
- Melamine was purchased from Sigma-Aldrich Chemicals.
Constituent 1
Results and discussion
Any other information on results incl. tables
The response of the T1 cells to the test substance melamine was positive and the lowest dose resulting in transformation of the cells was 10 ng/ml.
Applicant's summary and conclusion
- Executive summary:
The authors developed a new in vitro early-stage assay for testing both genotoxic and nongenotoxic carcinogens, and tested ca. 160 substances.
The test system used is based on a mouse cell line that carries bovine papilloma virus type 1 DNA (T1 assay).
The response of the T1 cells to the test substance melamine was positive and the lowest dose resulting in transformation of the cells was 10 ng/ml.
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