Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-615-4 | CAS number: 108-78-1
Endpoint summary
Administrative data
Description of key information
The incidences of urolithiasis in infants, particularly in China, caused by adulterated milk and formula are reported in a lot of papers, not all of them were included here. A recent summary and discussion of the incidences is provided by the paper of WHO in 2009. More recent investigations with exposed children are reported by e.g. Yang et al. 2010, Liu et al. 2010 and Guan et al. 2010.
Additional information
The incidences of urolithiasis in infants, particularly in China, caused by adulterated milk and formula are reported in a lot of papers, not all of them were included here. A summary and discussion of the incidences is provided e.g. by the paper of WHO in 2009, see Section 13. More recent investigations with exposed children are reported by e.g. Yang et al. 2010, Liu et al. 2010 and Guan et al. 2010.
Possible health effects of melamine at the workplace are reported in Chapter 7.10.3 and 7.10.4, but are of low relevance because of the poor description and not clear allocation of the effects to melamine itself. The repeatedly cited sensitisation study of Shaffer 1955 (also reported as American Cyanamid 1955) in the literature turned out to be an artefact. No sensitisation study is included in Shaffer 1955.
In Chapter 7.10.5 not health effects but exposure estimations or determinations were included, e.g. investigations of migration of melamine from tableware.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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