Registration Dossier
Registration Dossier
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EC number: 200-902-6 | CAS number: 75-79-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to microorganisms: 3hr EC50 > 100 mg/l in an activated sludge respiration inhibition test (OECD 209) for the read-across substance methyltrimethoxysilane, CAS 1185-55-3.
Key value for chemical safety assessment
Additional information
No data are available for the toxicity to microorganisms of the submission substance, trichloro(methyl)silane. However, an ASRI EC50 value of >100 mg/l (loading rate) has been determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP for the related substance methyltrimethoxysilane. Trichloro(methyl)silane and methyltrimethoxysilane both hydrolyse to methylsilanetriol with half-lifes at pH 7 of a few seconds and 2 h, respectively. The other hydrolysis products are hydrogen chloride and methanol, respectively; the properties of these substances are well characterised. Methanol is non-toxic to the environment and it is considered unlikely that it’s presence significantly affected the results of the test performed with methyltrimethoxysilane. Effects of hydrogen chloride on aquatic organisms are limited to those that result from changes to pH in unbuffered media.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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