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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Basic data given, no information on purity, vapour or aerosol

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1951

Materials and methods

Principles of method if other than guideline:
The test was conducted according to the method described by Smyth & Carpenter (1948).
Smyth & Carpenter (1948). J. Indust. Hyg. & Toxicol. 30: 63
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-Hydroxyethyl acrylate

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
other: vapour/aerosol
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
500 ppm (corresponding to approx. 2.4 mg/L)

Recalculation based on the equation c(mg/m3) = molar mass (g) / molar volume (L) x c(mL/m3) with molecular weight (116.12 g/mol) and molar volume (24.1 L at 20 °C and 1013 hPa) [DFG, MAK List, Wiley-VCH Verlag, 2008].
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Mortality:
Exposure to 500 ppm (2.4 mg/L) for 4 hours was lethal for 5 out of 6 animals.

Applicant's summary and conclusion