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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Sensitization to patch test acrylates.
Author:
Kanerva L et al.
Year:
1988
Bibliographic source:
Contact Dermatitis 18: 10-15

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Principles of method if other than guideline:
Data on allergic contact dermatitis from acrylates and 4 patients sensitized during routine patch testing were reported in the publication.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-Hydroxyethyl acrylate

Method

Type of population:
general
Ethical approval:
not specified
Subjects:
no data
Clinical history:
no data
Controls:
no controls
Route of administration:
dermal
Details on study design:
Type of test used: patch test (epicutaneous test)

Administration:
- Type of application: occlusive (Finn chamber method)
- Description of patch: The tests are applied on the back with a non-occlusive porous tape (Scanpor© Surgical Tape, Norgeplaster A/S, Norway) or on the thighs and then closed by a Finn chamber.
- Vehicle / solvent: petrolatum
- Concentrations: 0.5 % (w/w)
- Testing/scoring schedule: The tests are read on removal and 24 h, 48 h, and 96-120 after removal (at least 3 readings).
- Removal of test substance: after 24 h

Examinations: All readings are made by a dermatologist.

Results and discussion

Results of examinations:
Observations during 1985-1986:
- Number of subjects with positive reactions: 3/24 (diagnosed as having an occupational allergic contact dermatitis to acrylates)
- Number of subjects with negative reactions 12/24
- Number of subjects with irritating reactions 9/24 (3 of these were actively sensitized to 2-HEA among other acrylates)



Applicant's summary and conclusion