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EC number: 619-447-3 | CAS number: 99607-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 48 hours
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Guideline EG-1, 8/10/82
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable - Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken at the start and end of the exposure period.
- Vehicle:
- yes
- Details on test solutions:
- 200 mg of CGA 185072 technical and 8 mg alkylphenol polyglycolether were dispersed in and made up to 200 mL with water.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Strauss 1820
Cultures kept at the laboraotry since February 1983 under parthenogenic conditions.
Juveniles used for testing were less than 24 hours old.
Cultures were maintained in re-constituted water - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- 240 mg CaCO3/L
- Test temperature:
- 21 - 22 degrees C
- pH:
- 7.3 - 8.3
- Dissolved oxygen:
- Not measured during the study
- Salinity:
- No applicable
- Nominal and measured concentrations:
- Nominal concentrations 0 (water control), 0 (vehicle control), 10, 18, 32, 58, 100 mg/L.
Measured concentrations at T0 were 9.46, 18.4, 32.4, 57.4 and 101 mg/L and at T48 were 7.94, 10.6, 27.2, 52.3, 79.6 mg/L
The results of the study were based on the nominal exposure concentrations. - Details on test conditions:
- Measured environmental values were all in expected ranges.
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Details on results:
- Immobility after 48 hours was 0, 5, 15, 20 and 25% in the 10, 18, 32, 58 and 100 mg/L treatments. The 48 hour EC50 was observed to be >100 mg/L.
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- The results were based on observation of the data.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the reported information an acceptable assessment of acute toxicity to Daphnia magna was achieved.
- Executive summary:
An acute toxicity with Daphnia magna was conducted in which daphnids were exposed to series of concentrations on cloquintocet-mexyl. After 48 hours immobility was 0, 5, 15, 20 and 25% in the nominal 10, 18, 32, 58 and 100 mg/L treatments. The results are based on nominal exposure concentrations.
The 48 hour EC50 was observed to be >100 mg/L and the corresponding EC0 was 10 mg/L.
Reference
Immobility after 48 hours was 0, 5, 15, 20 and 25% in the 10, 18, 32, 58 and 100 mg/L treatments. The 48 hour EC50 was observed to be >100 mg/L and the corresponding EC0 was 10 mg/L.
Description of key information
Lowest 48-hour EC50 value >100 mg/L (nominal), water flea (EPA EG-1)
Lowest 48-hour EC50 value for the main metabolite >9.7 mg/L (nominal and mean measured), water flea (OECD TG 202)
Key value for chemical safety assessment
Additional information
In the key study (Rufli, 1988), 2 groups of 10 daphnids (Daphnia magna) were exposed to cloquintocet-mexyl at nominal concentrations of 10, 18, 32, 58 and 100 mg/L, in a static test for 48 hours. The 48-hour EC50 was >100 mg/L, the highest concentration tested. The no observed effect concentration was 18 mg/L. This GLP-compliant study was conducted to EPA guideline EG-1 and was considered to be reliable without restrictions.
In a second study (Palmer and Krueger, 1998), daphnids (Daphnia magna) were exposed to cloquintocet-mexyl at nominal concentrations of 0.063, 0.13, 0.25, 0.50 and 1.0 mg/L, in a flow-through test for 48 hours. The 48-hour EC50 for was >0.82 mg/L, the highest (measured) concentration tested. The no observed effect concentration was 0.82 mg/L. This GLP-compliant study was conducted to OECD guideline 202 and was considered to be reliable without restrictions.
Since both studies indicate that the EC50 is greater than the concentrations tested, it is proposed to select the upper of the two test concentrations as the key value for the endpoint. Therefore, for risk assessment purposes, the EC50 of >100 mg/L was used for cloquintocet-mexyl.
A study of short-term toxicity of the main metabolite of cloquintocet-mexyl to daphnids (Daphnia magna) was carried out (Putt, 1993) as a limit test. This GLP-compliant study was performed to OECD guideline 202 and is considered to be reliable without restrictions. Daphnids were exposed to a nominal concentration of 9.7 mg/L, in a semi-static system. No effects were observed at the test concentration, thus the 48-hour EC50 of the metabolite was determined to be >9.7 mg/L.
This demonstrates that cloquintocet-mexyl and its main environmental metabolite do not exhibit significant toxicity to aquatic freshwater invertebrates at or above the maximum water solubility of the substance, which is at about 0.59 mg/L at 25 °C.
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