Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 260-828-5 | CAS number: 57583-34-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate
- EC Number:
- 260-828-5
- EC Name:
- 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate
- Cas Number:
- 57583-34-3
- Molecular formula:
- C31H60O6S3Sn
- IUPAC Name:
- 2-ethylhexyl 10-ethyl-4-({2-[(2-ethylhexyl)oxy]-2-oxoethyl}sulfanyl)-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecan-1-oate
- Test material form:
- liquid
- Details on test material:
-
- Name of test material (as cited in study report): Methyltin tris (2-ethylhexylthioglycolate)
- Lot/batch No.: 1706-151
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague-Dawley, Inc., Indianapolis, IN
- Age at study initiation: naive young
- Weight at study initiation: 211-319 g for both sexes
- Fasting period before study: overnight prior to dosing
- Housing: housed in groups of 5
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days prior to being used in the test
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-26 degrees C
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12 hours light/ 12 hours dark
IN-LIFE DATES: From: July 30, 1996 To: August 22, 1996
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.50, 0.80, 1.25 and 3.15 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?) 14 days
- Frequency of observations and weighing: observed frequently for signs of systemic toxicity and mortality on the day of test initiation and at least twice daily thereafter; Body weights were measured at test initiation, Day 7 and post-mortem.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Statistics:
- LD50 values and 95 % confidence limits were calculated using the Litchfield and Wilcoxon method (1949)
Results and discussion
- Preliminary study:
- No data
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 880 mg/kg bw
- 95% CL:
- > 670 - < 1 150
- Remarks on result:
- other: reported as g/kg bw; results were converted to mg/kg bw
- Mortality:
- 0.50 g/kg bw: Males: no mortality; Females: 1 dead at 24 h
0.80 g/kg bw: Males: no mortality; Females: 2 dead at 24 h, 2 dead at 48 h
1.25 g/kg bw: Males: 3 dead at 24 h; Females: 4 dead at 24 h, 1 dead at 48 h
3.15 g/kg bw: Males: 5 dead at 24 h; Females: 5 dead at 24 h - Clinical signs:
- other: Clinical observations included depression, comatose, piloerection, eye squinting, hunched posture, labored breathing, ataxia, fecal stains, urine stains, and masticatory movement
- Gross pathology:
- Gross necropsy results (for animals that died during the test):
Lungs: pale, reddened, or mottled
Liver: pale or mottled with darkened edges, or white/blanched areas
Spleen: pale, darkened, or mottled
Pancreas: darkened
Kidneys: enlarged, pale, and/or congested
Stomach: distended
Intestines: reddened, distended, and contained a viscous yellow/orange fluid
Bladder: contained a red fluid, external staining noted
No gross pathological changes were noted in the surviving animals. - Other findings:
- Signs of systemic toxicity increased with increasing dose levels.
Applicant's summary and conclusion
- Interpretation of results:
- other: Classified as Category 4 in accordance with EU criteria
- Conclusions:
- LD50 880 mg/kg bw
- Executive summary:
The acute oral toxicity of undiluted Methyltin tris (2ethylhexylthioglycolate) was evaluated in compliance with the conditions specified in the regulation for the enforcement of the Federal Insecticide, Fungicide, and Rodenticide Act (40 CFR), the Toxic Substances Control Act (40 CFR) and OECD Guideline 401.
The test material was administered undiluted to groups of five male and five female Sprague Dawley rats at a dose level of 3.15 g/kg, 1.25 g/kg, 0.80 g/kg, and 0.50 g/kg. Following a single oral administration, the animals were observed for 14 days.
Based on the mortality observed, the acute oral LD50 value was calculated to be 0.88 g/kg with the 95% Confidence Limits of 0.67 g/kg and 1.15 g/kg. Clinical signs noted during the observation period included varying degrees of depression, comatose, piloerection, eye squinting, hunched posture, labored breathing, ataxia, fecal stains, urine stains, and masticatory movement. All surviving animals exhibited body weight gain at day 14. Gross necropsy findings for animals that died during the observation period included lungs pale, reddened, or mottled, liver mottled, liver pale and mottled with lower edge of lobes of liver darkened, areas of liver exhibit white blanching, areas of liver pale, spleen pale, darkened, or mottled, pancreas darkened, kidneys pale and/or congested, kidneys enlarged, stomach distended with gas, intestines reddened, intestines distended with gas, intestines contain a viscous yellow to orange fluid, urinary bladder contains a pale red fluid, and external staining. No gross pathological changes were noted in animals that survived the observation period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)