Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-03-24 to 2010-04-26
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of test material (as cited in study report): Alkenes, C11-12, hydroformylation products, distn. residues
- Substance type: pure Active Substance
- Physical state: liquid
- Storage condition of test material: Ambient condition in the dark

Results and discussion

Water solubility
Water solubility:
10.8 mg/L
Temp.:
20 °C
pH:
7.35
Remarks on result:
other: +/- 0.5 mg/L, CV = 5.0 %
Details on results:
The limit of quantification (LOQ) for the determination of test substance in reagent water was defined as 1.90 mg/L, calculated as the sum of the concentration of the lowest-level calibration standard (1.00 mg C/L) and the overall mean background in the reagent blank sample (0.495 mg C/L) divided by the %C in the test substance (78.68 %).

Any other information on results incl. tables

Table: Water solubility of the test substance at 20 °C
Sample Sampling Interval
[h]
Measured
[mg C/L]
Background corrected result
[mg/L]
Analytical result
{mg/L]
Mean analytical result ± SD
[mg/L]
% Difference
1 24 10.9 10.4 13.2 13.1 ± 0.8
(CV = 6.0%)
24 11.4 10.9 13.9
24 10.2 9.68 12.3
2 48 9.69 9.2 11.7 11.1 ± 058
(CV = 4.6%)
17
48 8.99 8.5 10.8
48 8.99 8.5 10.8
3 72 9.08 8.58 10.9 10.5 ± 0.4
(CV = 3.8%)
5.9
72 8.57 8.07 10.3
72 8.52 8.03 10.2
Overall mean =

10.8

SD = 0.5
CV = 5%
N = 6

SD = standard deviation; CV = coefficient of variation; N = Number of measurements

Background corrected result (mg C/L) = Measured result (mg C/L) - overall mean of the reagent blank (0.495 mg C/L)

Analytical result = Background corrected result (mg C/L) / %C in test substance (78.68%)

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of Alkenes, C11-12, hydroformylation products, distn. residues was determined in reagent water at 20 °C using the shake flask method. Solubility samples were collected and analysed using total carbon analysis (TOC). The mean net (background subtracted) solubility (n = 6) of the test substance at 20°C was 10.8 mg/L ± 0.5 mg/L (CV = 5.0 %)
Executive summary:

The water solubility of Alkenes, C11 -12, hydroformylation products, distn. residues was determined in reagent water at 20 °C using the shake flask method according to OECD Guideline of Testing of Chemicals No. 105: "Water Solubility". Solubility samples were collected and analysed using total carbon analysis (TOC). The mean net (background subtracted) solubility (n = 6) of the test substance at 20°C was 10.8 mg/L ± 0.5 mg/L (CV = 5.0 %)