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EC number: 235-469-2 | CAS number: 12237-63-7 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 45160:2.
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as-
WoE 2. and WoE 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Estimation method (if used):
- WoE 2: Structure estimation method
WoE 3: No data available - Remarks:
- WoE 2: The study was performed at pH 7.0 and 8.0, respectively.
- Remarks:
- WoE 3: Study was performed at pH range7.4 to 7.8 & 20.1 to 20.5⁰C,respectively. Test chemical conc. measured were 0.0287, 0.0320, 0.0334, 0.0349, 0.0251, 0.0311, 0.0414, 0.0370, 0.0362 & 0.0363 mg/l at 0, 1, 3, 6, 8, 10, 13, 15, 17 & 20 days,respectively.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- pH:
- 7
- DT50:
- 48 yr
- Type:
- second order
- Remarks on result:
- other: WoE 2: Hydrolysis rate constant of test chemical is 0.0046 L/mol-sec.
- pH:
- 8
- DT50:
- 5 yr
- Type:
- second order
- Remarks on result:
- other: WoE 2: Hydrolysis rate constant of test chemical is 0.0046 L/mol-sec.
- Remarks on result:
- other: WoE 3: Although half-life value of chemical was not known, but based on the measured concentration of test chemical in water, chemical appears to be in equilibrium and does not appear to be breaking down in water.
- Details on results:
- WoE 2: The half-life value of test chemical was determined to be 48 yrs and 5 yrs at pH 7 and 8, respectively and thus test chemical was reported to be hydrolytically stable.
WoE 3: Based on the measured concentration of test chemical in water, chemical was reported to be hydrolytically stable at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C for 20 days. Test chemical appears to be in equilibrium and does not appear to be breaking down in water. The concentration of test chemical is not decreasing with time. - Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 48 yrs and 5 yrs at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.0046 L/mol-sec, respectively or > 20 days at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is hydrolytically stable.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical . The studies are as mentioned below:
The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.0046L/mol-sec with a corresponding half-lives of 48 yrs and 5 yrs at pH 7 and 8, respectively. Based on the half-life value, it is concluded that the test chemical was considered to be hydrolytically stable.
The half-life of the test chemical was determined at different pH range. The study was performedat apH range7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively.The test substance was dissolved in dechlorinated tap water. The concentration of the test substance was measured in the supernatant of the test solution centrifuged. The test substance was measured on day 0, 1, 3, 6, 8, 10, 13, 15, 17, and 20 over a 21-day period. The test concentration used was considered to be at saturation in water. Based on the measured concentration of test chemical in water, chemical was reported to be hydrolytically stable at pH range7.4 to 7.8 and a temperature of 20.1 to 20.5 ⁰C for 20 days. Test chemical appears to be in equilibrium and does not appear to be breaking down in water. The concentration of test chemical is not decreasing with time. Thus, the half-life value of test chemical was determined to be > 20 days and on the basis of this, test chemical was considered to be stable in water.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 48 yrs and 5 yrs at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.0046 L/mol-sec, respectively or > 20 days at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is hydrolytically stable.
Reference
Description of key information
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 48 yrs and 5 yrs at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.0046 L/mol-sec, respectively or > 20 days at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is hydrolytically stable.
Key value for chemical safety assessment
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical . The studies are as mentioned below:
The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.0046L/mol-sec with a corresponding half-lives of 48 yrs and 5 yrs at pH 7 and 8, respectively. Based on the half-life value, it is concluded that the test chemical was considered to be hydrolytically stable.
The half-life of the test chemical was determined at different pH range. The study was performedat apH range7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively.The test substance was dissolved in dechlorinated tap water. The concentration of the test substance was measured in the supernatant of the test solution centrifuged. The test substance was measured on day 0, 1, 3, 6, 8, 10, 13, 15, 17, and 20 over a 21-day period. The test concentration used was considered to be at saturation in water. Based on the measured concentration of test chemical in water, chemical was reported to be hydrolytically stable at pH range7.4 to 7.8 and a temperature of 20.1 to 20.5 ⁰C for 20 days. Test chemical appears to be in equilibrium and does not appear to be breaking down in water. The concentration of test chemical is not decreasing with time. Thus, the half-life value of test chemical was determined to be > 20 days and on the basis of this, test chemical was considered to be stable in water.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 48 yrs and 5 yrs at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.0046 L/mol-sec, respectively or > 20 days at pH range 7.4 to 7.8 and a temperature of 20.1 to 20.5⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is hydrolytically stable.
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