Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Reliability rating was 1 because study followed OECD 117 partition coefficient (HPLC) test guideline and was carried out under GLP. The study was well-documented.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): MCP 2484
- Physical state: liquid, amber color
- Analytical purity: 100%

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
> 10
Temp.:
25 °C
pH:
7
Remarks on result:
other: HPLC method
Details on results:
Based on the calibration curve of the HPLC reference standards and the capacity factors for reference and test substances, it was extrapolated that the test substance has an experimentally determined log Kow >10 . Capacity factor k for the test substance was greater than that of didecyl phthlate.

Any other information on results incl. tables

see above results

Applicant's summary and conclusion

Conclusions:
The octanol water partition cofficient (Kow) was experimentally determined using the OECD 117 partition coefficient HPLC test method. The test substance had an experimentally determined log Kow > 10.
Executive summary:

The octanol water partition cofficient (Kow) was experimentally determined using the OECD 117 partition coefficient HPLC test method. The test substance had an experimentally determined log Kow > 10. This indicates that the test substance is highly lipophilic. The high log Kow >10 finding is consistent with the chemical structure, high MW and physico-chemical properties for the test substance.