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EC number: 204-909-5 | CAS number: 128-80-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two toxicity study of micro-organismsfor the test chemical :
1 . and 2. Tetrahymena pyriformis population growth impairment assay was carried out for 48 hr to study the effects of test chemical.
Toxicity to micro-organisms test was carried out according to the OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test. - GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- 2.This solvent h a s low toxicity to Tetrahymena , low volatility, a n d high ability to dissolve most organic chemicals. Concentrations no greater that t 0.75% DMSO (37 5 m L per 5 0 mL of medium) are used.
3. Toxicity to micro-organisms test was carried out according to the OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test. - Test organisms (species):
- other: 2. Tetrahymena pyriformis and 3.activated sludge
- Details on inoculum:
- 2. - Strain: GL
- Source: John R. Kennedy, Department of Biochemistry, Cell and Molecular Biology, The University of Tennessee -Knoxville - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- 2. 3 hr
- Test temperature:
- 2) 2 7 +- 1°C
- Details on test conditions:
- 2. TEST SYSTEM
- Test vessel: Erlenmeyer flasks
- Type (delete if not applicable): foam -stoppered closed
- Material, size, headspace, fill volume: 2 5 0 -m L - Duration:
- 48 h
- Dose descriptor:
- other: IGC50
- Effect conc.:
- 0.228 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Conclusions:
- The test chemical effect concentration value is in the range of 0.228 to >100 mg/L.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:
For structurally similar read across substance , tetrahymena pyriformis population growth impairment assay was carried out for 48 hr to study the effects of test chemical on micro-organisms. The population growth inhibition IGC50 to 50% of Tetrahymena pyriformis when exposed to test chemical for 48 hr under static condition is 0.228 mg/L.
In a data source for another read across substance toxicity to micro-organisms test was carried out according to the OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test.The 50% inhibition IC50 of micro-organsms when exposed to test chemical is >100 mg/L. The test chemical test material effect concentration value is in the range of 0.228 to >100 mg/L.
Reference
Description of key information
Toxicity to microorganisms:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:
For structurally similar read across substance , tetrahymena pyriformis population growth impairment assay was carried out for 48 hr to study the effects of test chemical on micro-organisms. The population growth inhibition IGC50 to 50% of Tetrahymena pyriformis when exposed to test chemical for 48 hr under static condition is 0.228 mg/L.
In a data source for another read across substance toxicity to micro-organisms test was carried out according to the OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test.The 50% inhibition IC50 of micro-organsms when exposed to test chemical is >100 mg/L. The test chemical test material effect concentration value is in the range of 0.228 to >100 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 100 mg/L
Additional information
Toxicity to microorganisms:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:
For structurally similar read across substance , tetrahymena pyriformis population growth impairment assay was carried out for 48 hr to study the effects of test chemical on micro-organisms. The population growth inhibition IGC50 to 50% of Tetrahymena pyriformis when exposed to test chemical for 48 hr under static condition is 0.228 mg/L.
In a data source for another read across substance toxicity to micro-organisms test was carried out according to the OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test.The 50% inhibition IC50 of micro-organsms when exposed to test chemical is >100 mg/L. The test chemical test material effect concentration value is in the range of 0.228 to >100 mg/L.
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