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EC number: 228-973-9
CAS number: 6381-77-7
Acute Oral Toxicity: LD50 = >5000 mg/kg bw Acute Dermal Toxicity: LD50 = >2000 mg/kg bw
In an acute oral toxicity study, 10 fasted albino rats were given a
single oral dose of 2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone
in a 50% aqueous suspension at a doses of 5000 mg/kg bw.
Oral LD50 = > 5000 mg/kg bw
The treated rats had soft, pasty stools within 3 hrs of dosing, followed
in 2 hrs by marked diarrhea that persisted for 24 hrs.
In an acute dermal toxicity, 6 rabbits were dermally exposed (intact and
abraded skin; occlusive exposure) to
2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone for 24 hours at a
dose of 2000 mg/kg bw. Animals then were observed for 14 days.
Dermal LD50 = > 2000 mg/kg bw
Behaviour, body weight gain, and consumption of feed and water were
normal, and no signs of toxicity were observed. No erythema, edema, or
other signs of dermal irritation were observed at five of six test
sites. One rabbit (abraded skin) had slight (1+) erythema at 24 hours
that cleared by 48 hours.
Acute inhalation toxicity is waived as the test substance has very low
vapor pressure and high melting point, so the potential for the
generation of inhalable forms is low, also the use of this substance
will not result in aerosols, particles or droplets of an inhalable size,
so exposure to humans via the inhalatory route will be unlikely to
occur, and no acute inhalation test was performed. Both acute oral and
dermal studies (basic methodological details provided) had a Klimisch
score of 2 and the results from both studies are acceptable to use in
the human health risk assessment.
Based on the available information in the dossier, the substance
2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone (CAS No. 6381-77-7)
does not need to be classified for acute toxicity or specific target
organ toxicity - single exposure when the criteria outlined in Annex I
of 1272/2008/EC are applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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