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Ecotoxicological information

Toxicity to microorganisms

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Link to relevant study record(s)

Description of key information

The Klimisch 1 activated sludge respiration inhibition study of Desmares-Koopmans (2003) performed at NOTOX according to OECD Guideline 209 and EU Method C.11 was considered as the key study. The EC50 for the test substance after 30 minutes of exposure exceeded 100 mg/L and can be used for PNEC derivation.

Key value for chemical safety assessment

Additional information

A single study was available on toxicity to microorganisms (Desmares-Koopmans, 2003). This study is an activated sludge respiration inhibition test performed at NOTOX in which the effect of the substance on respiration was investigated through 10-min measurements of oxygen consumption after a 30-min contact period. A control and a single concentration of 100 mg/L were tested in duplicate. In one of the duplicates at 100 mg/L no inhibition of the respiration rate of the sludge was recorded, whereas in the other a very slight inhibition (11%) was observed compared to the control. Therefore, no further testing was needed. The EC50 is > 100 mg/L. The results of this test are valid and reliable (Klimisch 1).