Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Following a qualitative judgement based on physico-chemical characteristics of the submitted substance (Groen, 2004), the substance will show a relatively high absorption after oral administration, mainly because of its high water solubility. If absorption occurs, the test substance will be extensively metabolised in the liver and rapidly excreted via bile and/or urine. Therefore, accumulation in the body during prolonged exposure will be very low. Dermal absorption is expected to be significant, following the log Pow and skin corrosive properties of the submitted substance. 

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

The qualitative judgement is based on physico-chemical characteristics. Some of these are determined under conditions which are not biologically relevant (like the octanol/water partition coefficient at pH 11). Furthermore, the submission substance is a multi constituent substance while physico-chemical characteristics in general refer to pure substances. The assessment should thus be treated with care.

Following a qualitative judgement based on physico-chemical characteristics of the submission substance (Groen, 2004), the substance will show a relatively high absorption after oral administration, mainly because of its high water solubility. If absorption occurs, the test substance will be extensively metabolised in the liver and rapidly excreted via bile and/or urine. Therefore, accumulation in the body during prolonged exposure will be very low. Dermal absorption is expected to be significant, following the logPow and skin corrosive properties of the submission substance.