Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
202-830-0
CAS no.:
100-21-0
Index number:
Molecular formula:
C8H6O4
SMILES:
OC(=O)C1=CC=C(C=C1)C(O)=O
InChI:
InChI=1S/C8H6O4/c9-7(10)5-1-2-6(4-3-5)8(11)12/h1-4H,(H,9,10)(H,11,12)
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
54
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye irritation, causes skin irritation and may cause respiratory irritation.

Breakdown of all 1302 C&L notifications submitted to ECHA

Not Classified
Skin Irrit. 2 H315
Eye Irrit. 2 H319
STOT SE 3 H335
Acute Tox. 4 H302
Eye Irrit. 2A H319
Repr. 2 H361
STOT SE 3 H336
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 161 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 to < 10 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: polymers, fuels and adhesives and sealants.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids) and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance is used in the following activities or processes at workplace: high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), laboratory work and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and as processing aid. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: laboratory chemicals, fuels and polymers.

This substance is used in the following areas: scientific research and development. This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: transfer of substance into small containers, laboratory work, roller or brushing applications, non-industrial spraying and transfer of chemicals.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use.

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers, laboratory work, industrial spraying and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and as processing aid.

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers, laboratory work, closed processes with no likelihood of exposure and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, manufacturing of the substance and formulation of mixtures.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, laboratory work, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, mixing in open batch processes, industrial spraying and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and as processing aid.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ADVANSA Manufacturing GmbH, Frielinghauser Strasse 5 59071 Hamm Nordrhein-Westfalen Germany
  • AdvanSix Resins & Chemicals (Ireland) Limited, 13-18 City Quay D02 ED70 Dublin Ireland Ireland
  • Allnex Belgium NV/SA OR1, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Belgium OR3, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Italy S.R.L., Via Matteo Bianchin, 62 36060 Romano d'Ezzelino Italy
  • ALPLA Werke Alwin Lehner GmbH & Co KG, Allmendstraße 81 6971 Hard Austria
  • Amcor Flexibles Valkeakoski Oy, PO Box 70 Niementie 161 37601 Valkeakoski Finland
  • Armacell Benelux S.C.S., Rue des Trois Entités 9 4890 Thimister-Clermont Belgium
  • Arpadis Benelux NV, Desguinlei 88A 2018 Antwerp Belgium
  • Bantam EU , Unit 19 Docklands Innovation Park 3 Dublin Ireland
  • BASF Schwarzheide GmbH, Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BCI POLYURETHANE EUROPE SRL, P.le Cocchi 22 (Z.I) 21040 Vedano Olona (VA) Italy
  • BCS Only Representative Services Ltd 002, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • BCS Only Representative Services Ltd 014, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • BiSafe d.o.o. (OR Alwag), V Kladeh 11c 1000 Ljubljana Slovenia
  • BiSafe d.o.o. (OR Başatlı Boru Profil San. Tic. A.Ş.), V Kladeh 11c 1000 Ljubljana Slovenia
  • Blue Frog Scientific EURL - EU OR1, 967 Route de la Plaine La Plaine 26400 Chabrillan France
  • Blue Frog Scientific EURL EU OR6, 967 Route de la Plaine La Plaine 26400 Chabrillan France
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • BOSTIK S.A._02, 420, rue d’Estienne d’Orves 92705 Colombes Cedex France
  • CARBIOS, Site de Cataroux 8 rue de la Grolière 63100 CLERMONT-FERRAND France
  • Carpenter Belgium NV, Wijnendalestraat 171 B-8800 Roeselare Belgium
  • CCD (Germany) GmbH, Berliner Allee 55 40212 Düsseldorf Germany
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • CEPRA srl, Via del Tintoretto, 6/2 40033 casalecchio di reno Bo Italy
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(GUIZHOU DONGFENG ANTIMONY CO.,LTD), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(Xinjiang Korla Zhongtai Petrochemical Co., Ltd.), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION ®ULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemservice GmbH - (9T2U), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chemservice GmbH - (C8U9), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chemservice GmbH - (D1Y0), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chemservice GmbH - (I1T3), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chemservice S.A. (BSR7), 13, Fausermillen 6689 Mertert Luxembourg
  • Chemservice S.A. – (L8U4), 13, Fausermillen 6689 Mertert Luxembourg
  • Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • CHT Germany GmbH, Bismarckstr. 102 72072 Tuebingen Germany
  • CRCP GmbH, Am Römerhof 51 60486 Frankfurt am Main Germany
  • Dak Americas Exterior, S.L., CALENDULA 95, EDICIFIO M, OFICINA 5 28109 ALCOBENDAS MADRID/SPAIN Spain
  • DAK AMERICAS EXTERIOR, S.L.U., CALENDULA 95, EDIFICIO M, OFICINA 5 28109 ALCOBEDNAS MADRID/SPAIN Spain
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW CHEMICAL IBERICA S.L., Ribera del Loira 4-6 Edificio Iris, 4º Planta 28042 Madrid Spain
  • Eastman Chemical B.V., Watermanweg 70 3067 GG Rotterdam Netherlands
  • EcoMundo, 215, rue Jean-Jacques Rousseau 92130 Issy-les-Moulineaux France
  • ELC group s.r.o, Karolinska 650/1 186 00 Prague 8 ECHA-04f00bd6-4442-42bb-be87-2a71f23307f0 Czech Republic
  • EMERAUDE INTERNATIONAL, 2 rue de la Tour des Dames 75009 Paris France
  • Emond BVBA, Waterwilgweg 6 2050 Antwerp Belgium
  • Equipolymers GmbH, Site/Werk Schkopau Building K80 D-06258 Schkopau Germany
  • EVI S.r.l., Via Lanzone, 31 20123 Milano (MI) Lombardia Italy
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17, 22363 Lund Sweden
  • Hengli ( Germany ) GmbH, Mergenthaler Allee 45 65760 Eschborn Germany
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • Indorama Ventures Europe B.V., Markweg 201 3198 NB Europoort (Rotterdam) Netherlands
  • Indorama Ventures Europe B.V., Markweg 201 3198NB Europoort (Rtd) Netherlands
  • Indorama Ventures Europe BV, Markweg 201 Harbour number 6347 3198 NB Europoort, Rotterdam South-Holland Netherlands
  • Indorama Ventures Europe BV, Markweg 201 3198NB Europoort Netherlands
  • Indorama Ventures Europe BV, Markweg 201 3198 NB Europoort (Rotterdam) Netherlands
  • Indorama Ventures Polymers Germany GmbH, Philipp Reis Strasse 4 65795 Hattersheim Germany
  • Indorama Ventures Portugal PTA, Unipessoal Lda, ZILS, Zona 2, Lote 2E1, Monte Feio 7520-064 Sines Portugal
  • INDORAMA VENTURES QUÍMICA S.L.U., Polígono Industrial Guadarranque, 0, sin número 11360 San Roque Cádiz Spain
  • Ineos Aromatics Belgium NV, Amocolaan 2 2440 Geel Belgium
  • INEOS Aromatics Limited, Amocolaan 2 2440 Geel Belgium
  • Intertek Deutschland GmbH 53, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 95, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH_UKBW2020, Stangenstr.1 70771 Leinfelden- Echterdingen Germany
  • Intertek Italia SpA, Via Miglioli 2/A 20063 CERNUSCO SUL NAVIGLIO, Milano Italy
  • JBF GLOBAL EUROPE BVBA, NIJVERHEIDSWEG 4 2430 LAAKDAL Belgium
  • Kao Chemicals Europe, S.L. (10), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Klaus F. Meyer GmbH, Leiblstraße 3 67136 Fussgoenheim Germany
  • Knoell NL_OR_084, Agro Business Park 75 – 83 6708 PV Wageningen Netherlands
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Labcorp Development SA 023, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Labcorp DEVELOPMENT SA 087, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 136, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 155, Parque Empresarial Las Tablas, Edifico 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Manuchar NV, Rietschoorvelden 20 2170 Merksem Belgium
  • MHM Holding GmbH, Sonnenallee 1 D-85551 Kirchheim Germany
  • Mitsubishi Polyester Film GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • Mitsubishi_Chemical_Europe_GmbH, Schiessstraße 47 40549 Düsseldorf Germany
  • Mitsui and Co. Benelux S.A./N.V., Treurenberg 2 1000 Brussels Belgium
  • Märkische Faser GmbH, Grisutenstr. 13 14727 Premnitz Germany
  • NAM & NAM Europe GmbH, Am Kronberger Hang 2 65824 Schwalbach Germany
  • NAM & NAM Europe GmbH, Am Kronberger Hang 2 65824 Schwalbach Germany Germany
  • Nam&Nam Europe GmbH, Am Kronberger Hang 2 65824 Schwalbach Germany
  • NEARCHIMICA S.p.a, Via F.lli Rosselli 50,52 20025 Legnano - Milano Italy
  • NHU Performance Materials GmbH, Daimlerstr. 14-16 21357 Bardowick Germany
  • Novamont, via Fauser 8 28100 Novara Italy
  • NOVAPET SA, Paseo Independencia nº21, 3ª planta 50001 Zaragoza Spain
  • Oerlikon Textile GmbH & Co. KG, Leverkuser Str. 65 42897 Remscheid Germany
  • Only representative (No publishable name), null
  • Ottana Polimeri Srl, Strada Provinciale 17, Km 18, Zona Industriale 08020 Ottana Nu Italy
  • OWIM GmbH & Co. KG, Stiftsbergstr. 1 74172 Neckarsulm Germany
  • PACCOR Packaging GmbH, Marienburgstrasse 25a 56856 Zell (Mosel) Germany
  • PARAMELT B.V., Costerstr. 18 1704 RJ Heerhugowaard Netherlands
  • PetroChina International (Netherlands) Company B.V, Toren A, 11th Floor 3012NJ Rotterdam Netherlands
  • PlasticFinder S.r.l., Via Cappuccini, 6 20122 Milano Italy
  • Plastics For Change OÜ, Plastics For Change C/O E-Residency Hub OÜ Harju maakond EE-Ahtri tn 12, KESKLINNA LINNAOSA 10151 TALLINN Estonia
  • PLUTO INTERNATIONAL S.R.L., VIALE XII GIUGNO N° 15 40124 Bologna Italy
  • Polski Koncern Naftowy ORLEN SA, ul. Chemików 7 09-411 Płock Poland Poland
  • POLYNT S.p.A., via Enrico Fermi, 51 I-24020 Scanzorosciate BG Italy
  • Polytrade Global GmbH, Borsigallee 12 60388 Frankfurt am Main Hessen Germany
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman, 6 B-1040 Brussels Belgium
  • Reach Only Representative (Ireland) Ltd (shakesp), VPR House Main Street F12 FC64 Swinford County Mayo Ireland
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H Consulting Group (acts as OR for Jiangsu Ceville New Materials Technology Co., Ltd.), Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP(act as OR for JIANGSU HONGGANG PETROCHEMICAL CO., LTD.), Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACHLaw Ltd, Aleksanterinkatu 19 00100 Helsinki Finland
  • Resilux NV, Damstraat 4 9230 Wetteren Belgium
  • RHODIA OPERATIONS, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 LYON France
  • Ricardo Nederland BV, Catharijnesingel 33 3511 GC Utrecht Netherlands
  • rSupply GmbH, Schulze-Delitzsch-Str. 24 68542 Heddesheim Germany
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • SHPP B.V., Plasticslaan 1 4612PX Bergen op Zoom Netherlands
  • SILICONATURE S.p.A. , Via Nazionale 39 31010 GODEGA DI S.URBANO (TV) Italy
  • SINTERAMA S.P.A., via gramsci 5 13876 sandigliano Italy
  • SKC Oktachim s.r.o., Spitalska 53 81101 Bratislava Slovakia
  • Société d’injection des bouchons, 35 rue des jeuneurs 75002 Paris France
  • Solvay Specialty Polymers Italy S.p.A., Viale Lombardia 20 20021 BOLLATE Italy
  • Solvay Specialty Polymers Italy_OR, Viale Lombardia 2020021 BOLLATE Italy
  • Steinbeis PolyVert GmbH, Werner-Heisenberg-Straße 5 9100 Völkermarkt Austria
  • Stepan Netherlands B.V., Maltaweg 3-2 4389 PV RITTHEM Netherlands
  • STEPAN POLSKA, Urazka Street PL 56-120 Brzeg Dolny Poland
  • Synthomer Trading Limited Dutch Branch, Ijesselstraat 41 5347 KG Oss Netherlands
  • TEAM mastery S.r.l., Via Ferrari 14 22100 Como Italy
  • Teknor Apex BV, Urmonderbaan 22 Urmonderbaan 22, (P.O.Box 601, 6160 AP) 6167 RD Geleen Netherlands
  • The Acta Group EU BVBA (BE31), Place du Luxembourg 2 1050 Brussels Belgium
  • Toyota Tsusho Europe S.A., Belgicastraat 13 1930 Zaventem Belgium
  • Tricon Energy Iberica, S.L.U., Avenida Pau Casals, nº 14, 6º piso, 08021 Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (020), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (054), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (055), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia, S.A.U., Ronda Can Fatjó, 13 08290 Cerdanyola del Vallès (Barcelona) Spain
  • UAB NEO GROUP, Industrijos str. 2 LT-95346 Rimkai village, Dovilai Eldership Klaipėda District Lithuania
  • Veolia PET Germany GmbH, Dierkower Damm 29 18146 Rostock Germany
  • Wellman International, Mullagh Co. Meath Kells Meath Ireland
  • Yordas GmbH, Äußere Nürnberger Straße 62 91301 Forchheim Germany
  • [Confidential], [Confidential]
  • Cambridge Environmental Assessments, part of ADAS UK Ltd, ADAS Boxworth Battlegate Road, Boxworth CB23 4NN Cambridge Cambridgeshire United Kingdom
  • CRCP GmbH, Am Römerhof 51 60486 Frankfurt am Main Germany
  • HH Compliance Ltd., Rubicon-Building, CIT-Campus Bishopstown none Cork Ireland
  • Huntsman (Europe) BV - OR5, Everslaan 45 B-3078 Everberg Belgium
  • Intertek deutschland GmbH TTPI, Stangenstr. 1 70771 Leinfelden-Echterdingen Germany
  • PCK RAFFINERIE GMBH, Passower Chaussee 111 16303 Schwedt/Oder Germany
  • Petrochemical Commercial Company (UK) Ltd, 24, GROSVENOR GARDENS SW1W 0DH LONDON EUROPE United Kingdom
  • REACH NATION 2, Avenue du Pesage 18, Box 9 1050 Brussels Belgium
  • REACHLaw Ltd, Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • The Acta Group EU BVBA (BE4), Place du Luxembourg 2 1050 Brussels Belgium
  • The Acta Group EU, LTD (12), Brook House Suite 2B 64-72 Spring Gardens M2 2BQ Manchester United Kingdom
  • [Confidential], [Confidential]

Substance names and other identifiers

1,4-Benzenedicarboxylic acid
Other
Acide terephtalique
Other
Kyselina tereftalova
Other
p-Benzenedicarboxylic acid
Other
p-Carboxybenzoic acid
Other
p-Dicarboxybenzene
Other
p-Phthalic acid
Other
para-Phthalic acid
Other
TA 12
Other
TA-33MP
Other
Tephthol
Other
Terephthalic acid
EC Inventory, REACH pre-registration, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
Terephthalic acid
REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
1,4-Benzenedicarbocyclic acid
Registration dossier
1,4-benzenedicarbossilic acid
Registration dossier
1,4-Benzenedicarboxylic acid
C&L Inventory, Registration dossier
1,4-Benzenedicarboxylic acid
C&L Inventory, Registration dossier
1.4 benzene dicarboxylic acid
C&L Inventory
Benzene-1,4-dicarboxylic acid
C&L Inventory, Registration dossier, Other
benzene-1,4-dicarboxylic acid
C&L Inventory, Registration dossier, Other
p-Phthalic acidPTA (Purified Terephthalic Acid)
Registration dossier
PTA
Registration dossier
Purified terephtalic acid (PTA)
Registration dossier
Purified Terephtalic Acid.
Registration dossier
Purified Terephthalic Acid
Registration dossier
Purified Terephthalic Acid, PTA
Registration dossier
purified terephthalic acidPTA
Registration dossier
terephtalc acid
C&L Inventory
terephtalic acid
C&L Inventory
Terephtalic acid.
Registration dossier
TEREPHTHALIC ACID
C&L Inventory, Registration dossier, Other
TEREPHTHALIC ACID
C&L Inventory, Registration dossier, Other
terephthalic acid
Registration dossier
Terephthalic acid - Masab Inquiry dossier
Registration dossier
terephthalic acid, TPA
Registration dossier
Terephthalic Pure Acid
Registration dossier
1,4-Benzenedicarboxylic acid (9CI)
Registration dossier
1,4-Dicarboxybenzene
Registration dossier
AE-2030
Registration dossier
AE-2130
Registration dossier
AE-2150
Registration dossier
AE-2230
Registration dossier
Benzene 1-4,-dicarboxylic acid
Registration dossier
GC-0700
Registration dossier
GC-0730
Registration dossier
p-benzene dicarbolic acid
Registration dossier
p-Benzenedicarboxylic acid
Registration dossier
p-Carboxybenzoic acid
Registration dossier
p-Dicarboxybenzene
Registration dossier
p-Phthalic acid
Registration dossier
PTA
Registration dossier
PTA (PURIFIED TEREPHTHALIC ACID)
Registration dossier
Purified Terephthalic Acid (PTA)
Registration dossier
Purified tetephthalic acid
Registration dossier
TA
Registration dossier
TA-33
Registration dossier
Terephtalic acid
Registration dossier
TEREPHTHALIC ACID
Registration dossier
Terephthalic acid (7CI, 8CI)
Registration dossier
TPA
Registration dossier
WR 16262
Registration dossier
1,4-Benzene dicarboxylic acid
REACH pre-registration
1,4-Benzenedicarboxylic acid
REACH pre-registration
Terephthalic acid
REACH pre-registration
100-21-0
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
2088100-81-4
CAS number
Other
211863-90-0
CAS number
Other
211863-92-2
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: particulate/powder (100%)
Colour
colourless (50%), white (50%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 1 study processed
R Melting / freezing point
427 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 3 studies submitted
  • 1 study processed
R Vapour pressure
0.001 - 0.002 Pa @ 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0.002 Pa @ 25 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 1 study processed
R Log Pow
1.76 - 2 @ 25 °C and pH 3.9 [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
2 @ 25 °C

Water solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
17 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Non-explosive (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
3.54 - 4.46 @ 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
13 days

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
18.28

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 380 µg/L (2)
Intermittent releases (freshwater) 1.9 mg/L (2)
Marine water 38 µg/L (2)
Intermittent releases (marine water) 1.9 mg/L (1)
Sewage treatment plant (STP) 50 mg/L (2)
Sediment (freshwater) 520 - 2 060 µg/kg sediment dw (2)
Sediment (marine water) 52 - 206 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 189 - 710 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 18.6 - 961 mg/L [3]
NOEC (4 days) 18.6 - 961 mg/L [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 4
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 20.1 - 967 mg/L [3]
NOEC (48 h) 20.1 - 967 mg/L [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 4
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 19.5 mg/L [2]
EC50 (21 days) 19.5 mg/L [1]
LC50 (21 days) 19.5 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
EC50 (72 h) 19 mg/L [3]
NOEC (4 days) 668 - 1 000 mg/L [4]
NOEC (72 h) 19 mg/L [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater algae
19 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 1.393 g/L [2]
NOEC (3 h) 500 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
1.393 g/L
EC10 or NOEC for microorganisms
500 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 15 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 21 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 11 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.25 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 1
Weight of evidence 10
Other
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 85 %
Dermal: 10 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 15 380 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 1.01 mg/L air (rat) [1]
LC50 (2 h) 2.02 mg/L air (rat) [1]
M/CInterpretations of results
Not classified [1]

inhalation
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 15 380 mg/kg bw
Inhalation route:
No adverse effect observed LC50 2.02 mg/L air
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 7 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 277 - 309 mg/kg bw/day [2]
NOAEL (rat): 1 250 ppm [1]
LOEL (rat): 300 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence 4 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 2 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 10.05 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 125 mg/kg bw/day (subchronic, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 10 mg/m³ (subacute, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 10 mg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study
Weight of evidence 3 4
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No study available (further information necessary)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed NOAEL 142 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study 1 1
Weight of evidence 3 2
Other 1
Data waiving
no waivers
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 491.6 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 198 mg/kg bw/day (subacute, mouse)
Inhalation route:
No adverse effect observed NOAEC 10 mg/m³ (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant