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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds
Author:
Schafer, Edward W
Year:
1972
Bibliographic source:
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
Reference Type:
review article or handbook
Title:
RTECS Number: BY7000000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances); TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
standard acute method
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitroaniline
EC Number:
202-810-1
EC Name:
4-nitroaniline
Cas Number:
100-01-6
Molecular formula:
C6H6N2O2
IUPAC Name:
4-nitroaniline
Details on test material:
- Name of test material (as cited in study report): 4-nitroaniline
- Substance type: Organic
- Physical state: solid

Test animals

Species:
other: Bird - wild bird species
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
75 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The lethal dose value (LD50) causing acute oral toxicity to wild bird species is 75 mg/kg body weight. This value indicates that 4-nitroaniline shall exhibit acute oral toxicity Category III to birds as per the CLP criteria. This is in agreement with the harmonized system of classification for 4-Nitroaniline.
Executive summary:

The lethal dose value (LD50) causing acute oral toxicity to wild bird species is 75 mg/kg body weight. This value indicates that 4-nitroaniline shall exhibit acute oral toxicity of the level of Category III to birds as per the CLP criteria.