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EC number: 207-975-3 | CAS number: 503-74-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No valid data could be located regarding the short-term toxicity of isovaleric acid to aquatic invertebrates.
To compensate for this lack of data, information resulting from isobutyric acid as supporting substance is used.
Supporting substance isobutyric acid: in a valid Daphnia magna acute immobilization test similar to OECD TG 202, the EC50 of isobutyric acid was determined to be 51.25 mg/L (BASF AG, 1989)
Taking into account the molecular weights of isovaleric acid (102.13) and isobutyric acid (88.11), an EC50 of 59.4 mg/L for isovaleric acid can be calculated.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 59.4 mg/L
Additional information
For the toxicity assessment of isovaleric acid to aquatic invertebrates, valid data could not be identified. Data for isobutyric acid as supporting substance will be used based on following reasons.
Both acids are closely related. Their carbon chain differs only in one carbon atom. Physical and physico-chemical properties as well as chemical reactivity will be quite similar. Main structural feature is the carboxylic acid group, which will have a major impact on the effects of both substances in aquatic systems. Thus, it is justified to use isobutyric acid as supporting substance in the evaluation of the short-term toxicity of isovaleric acid to aquatic invertebrates.
Supporting substance isobutyric acid
BASF AG 1989
Isobutyric acid was tested on the waterflea Daphnia magna in a 48-h acute immobilization test similar to OECD TG 202 under static conditions at concentrations of 0 (water control), 15.625, 31.3, 62.5, 125, 250, and 500 mg/L. Immobilization and other toxic effects were observed 3, 6, 24, and 48 h after initiation of the test.
The 48-h EC50 was determined to be 51.25 mg/L (BASF AG, 1989).
Isovaleric acid: short-term toxicity to aquatic invertebrates
Taking into account the molecular weights of isovaleric acid (102.13) and isobutyric acid (88.11), an EC50 of 59.4 mg/L for isovaleric acid is calculated.
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