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Diss Factsheets
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EC number: 204-594-4 | CAS number: 123-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (pre-GLP; application time 20 h; occlusive coverage; only 2 animals used; short observation period (8 days)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Principles of method if other than guideline:
- The test substance was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 20 h under occlusive conditions. The skin was intact. After the application time, the skin was washed with water which may have contained a mild detergent. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24 and 48 hours and at the end of the observation period. Findings were graded as described in OECD guideline 404 (according to Draize).
- GLP compliance:
- no
- Remarks:
- GLP was not compulsory at the time the study was conducted
Test material
- Reference substance name:
- Ethylhexylchloride
- IUPAC Name:
- Ethylhexylchloride
- Details on test material:
- - Name of test material (as cited in study report): Ethylhexylchloride
- Physical state: liquid
- Purity: ca. 98%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler
- Age at study initiation: young adult
- Weight at study initiation: animal 1: 2.13 kg; animal 2: 2.21 kg
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied (volume): approx. 0.5 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- The test substance was applied for 1 min, 5 min, 15 min and 20 h. The irritation scores from the 20-hour exposure period were taken to assess skin irritation by the test substance.
- Observation period:
- 8 days
- Number of animals:
- 2 (males)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- Type of wrap if used: occlusive
REMOVAL OF TEST SUBSTANCE
- Washing: yes, with water which may have contained a mild detergent
- Time after start of exposure: 1 min, 5 min, 15 min, 20 h
SCORING SYSTEM: as described in OECD guideline 404 (according to Draize)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24-48 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusive exposure, 72-hour assessment timepoint missing, short observation period (8 days)
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24-48 hours
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 20 h occlusive exposure, 72-hour assessment timepoint missing, short observation period (8 days)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24-48 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: squamation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24-48 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: squamation
- Irritant / corrosive response data:
- See table below.
- Other effects:
- - Weight at study termination: animal 1: 2.38 kg; animal 2: 2.3 kg
Any other information on results incl. tables
Irritation scores (20 h occlusive exposure):
Timepoint |
Animal No. |
Intact skin |
Symptoms |
|
Erythema |
Edema |
|||
24 h |
1 |
3 |
0 |
|
2 |
2 |
0 |
|
|
48 h |
1 |
3 |
0 |
|
2 |
3 |
0 |
|
|
8 d |
1 |
2 |
0 |
Squamation |
2 |
2 |
0 |
Squamation |
|
Mean 24, 48 h |
1 |
3 |
0 |
|
Mean 24, 48 h |
2 |
2.5 |
0 |
|
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Conclusions:
- According to the results of this study the test substance is considered to be irritating to the rabbit skin.
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