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Diss Factsheets
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EC number: 204-594-4 | CAS number: 123-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (pre-GLP, short observation period)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- In principle, the methods described in the OECD Guideline 401 were used. Young adult laboratory rats were purchased from breeder. Usually the source and strain of animals were not documented. Several groups of 10 rats per sex and dose were treated simultaneously by gavage with preparations of the test substance in suitable vehicle. The concentrations of these preparations were used to achieve comparable volumes per kg body weight. Group-wise documentation of clinical signs was performed over the 7 day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose.
- GLP compliance:
- no
- Remarks:
- GLP was not compulsory at the time the study was conducted
- Test type:
- standard acute method
Test material
- Reference substance name:
- Ethylhexylchloride
- IUPAC Name:
- Ethylhexylchloride
- Details on test material:
- - Name of test material (as cited in study report): Ethylhexylchloride
- Physical state: liquid
- Purity: ca. 98%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Mean body weight at study initiation:
0.2 ml/kg bw dose group: males: 231 g / females: 196 g
1.6 ml/kg bw dose group: males: 231 g / females: 200 g
3.2 ml/kg bw dose group: males: 247 g / females: 191 g
6.4 ml/kg bw dose group: males: 244 g / females: 191 g
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: traganth
- Details on oral exposure:
- DOSAGE PREPARATION:
- Stock solutions prepared:
2% for the 0.2 ml/kg bw dose group;
20% for the 1.6 ml/kg bw dose group;
30% for the 3.2 and 6.4 ml/kg bw dose groups.
- Dose volume applied:
10 ml/kg bw of the 2% stock solution for the 0.2 ml/kg bw dose group;
8 ml/kg bw of the 20% stock solution for the 1.6 ml/kg bw dose group;
10.6 ml/kg bw of the 30% stock solution for the 3.2 ml/kg bw dose group;
21.3 ml/kg bw of the 30% stock solution for the 6.4 ml/kg bw dose group. - Doses:
- 0.2; 1.6; 3.2; 6.4 ml/kg bw,
corresponding to 177; 1413; 2827; 5653 mg/kg bw (calculated using the relative density of 0.8833 g/cm³ (@ 20°C)) - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days;
- The animals were observed for mortality and clinical signs of toxicity;
- Frequency of observations: Several times on the application day, thereafter once each working day;
- Body weights were only recorded at the beginning of the study;
- Necropsy of survivors and animals that died performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 653 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated from original data using the relative density of 0.8833 g/cm³
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6.4 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original data
- Mortality:
- No mortalities in 0.2, 1.6 and 3.2 ml/kg bw dose groups; 1/20 (one female) in the 6.4 ml/kg bw dose group (see table below).
- Clinical signs:
- other: 0.2 ml/kg bw dose group: No symptoms. 1.6 ml/kg bw dose group: Immediately after application high stepping gait, agitated behavior, accelerated respiration and in the afternoon squatting posture, piloerection, eyelid closure and hardly visible respiration
- Gross pathology:
- Animal that died:
- serously smeared mouth, strongly extended gastrointestinal tract with decay
Animals sacrificed:
- nothing abnormal detected
Any other information on results incl. tables
Mortality data:
Dose (ml/kg) |
0.2 |
1.6 |
3.2 |
6.4 |
Dose (mg/kg) |
177 |
1413 |
2827 |
5653 |
|
|
|
|
|
Males: Number of animals |
10 |
10 |
10 |
10 |
Dead animals after: |
|
|
|
|
1 h |
0 |
0 |
0 |
0 |
1 d |
0 |
0 |
0 |
0 |
2 d |
0 |
0 |
0 |
0 |
7 d |
0 |
0 |
0 |
0 |
|
|
|
|
|
Females: Number of animals |
10 |
10 |
10 |
10 |
Dead animals after: |
|
|
|
|
1 h |
0 |
0 |
0 |
0 |
1 d |
0 |
0 |
0 |
0 |
2 d |
0 |
0 |
0 |
0 |
7 d |
0 |
0 |
0 |
1 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of the test the LD50 for male and female rats after oral application is > 6.4 ml/kg bw/5653 mg/kg bw.
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