Registration Dossier
Registration Dossier
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EC number: 202-784-1 | CAS number: 99-75-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Robust Summaries For Benzyl Derivatives; Submitted to the EPA under the HPV Challenge Program by: The Flavor and Fragrance High Production Volume Chemical Consortia
- Author:
- US EPA HPV
- Year:
- 2 001
- Bibliographic source:
- http://www.epa.gov/hpv/pubs/summaries/benzylde/c13450rs.pdf
- Report date:
- 2001
- Reference Type:
- secondary source
- Title:
- SCREENING-LEVEL HAZARD CHARACTERIZATION Benzyl Derivatives Category
- Author:
- US EPA HPV
- Year:
- 2 010
- Bibliographic source:
- http://www.epa.gov/chemrtk/hpvis/hazchar/Category_Benzyl%20Derivatives_September_2010.pdf
Materials and methods
- Principles of method if other than guideline:
- standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl p-toluate
- EC Number:
- 202-784-1
- EC Name:
- Methyl p-toluate
- Cas Number:
- 99-75-2
- Molecular formula:
- C9H10O2
- IUPAC Name:
- methyl 4-methylbenzoate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- not stated
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortality observed
Any other information on results incl. tables
No toxic effects were reported. Mild to severe redness and mild to moderate edema were observed.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the dermal LD50 in rabbits was > 5000 mg/kg bw
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