Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-784-1 | CAS number: 99-75-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset Substance ID: 99-75-2
- Author:
- IUCLID
- Year:
- 2 000
- Bibliographic source:
- http://esis.jrc.ec.europa.eu/ with reference to Montefibre S.p.A
- Report date:
- 2000
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs. Methyl p-toluate
- Author:
- Opdyke DLJ
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology, Vol. 17 Suppl. 183-184
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Skin irritation test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl p-toluate
- EC Number:
- 202-784-1
- EC Name:
- Methyl p-toluate
- Cas Number:
- 99-75-2
- Molecular formula:
- C9H10O2
- IUPAC Name:
- methyl 4-methylbenzoate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 h
- Observation period:
- no data
- Number of animals:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: no data
- Remarks on result:
- other: moderately irritating
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the test substance was moderately irritating (applikation to intact or abraded rabbit skin for 24 hours under occlusion).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
