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EC number: 406-420-4
CAS number: 69430-40-6
The observed skin irritation consisted of well defined erythema and very
slight or slight oedema in the three animals. The skin irritation was
reversible within 14 days after exposure in all animals.
No staining of the treated skin by the test substance was observed.
There was no evidence of a corrosive effect on the skin.
No symptoms of systemic toxicity were observed in the animals during the
test period and no mortality occurred.
The purpose of this study was to assess the possible irritation or
corrosion potential of DC5067 when a single dose was placed on the skin
of rabbits. This study was carried out in accordance with OECD Guideline
Number 404, "Acute Dermal Irri tation/Corrosion and EEC Directive
84/449/EEC, Part 8.4, "Acute Toxicity-Skin Irritation". DC5067 was
applied on the shaved skin of three female rabbits using semi-occlusive
dressings for 4 hours, followed by six observations at approximately 1,
24, 48 and 72 hours and 7 and 14 days after removal of the dressings and
the remaining test substance. Under the conditions of this study, DC5067
resulted in well defined erythema and very slight or slight oedema in
the three animals. The skin irritation was reversible within 14 days
after exposure in all animals. In the area of application, no staining
of the treated skin in any of the rabbits. No signs of systemic
intoxication were observed during the study period.
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