Registration Dossier
Registration Dossier
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EC number: 942-597-9 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January - February 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- GR-50-1408 is the Givaudan identification code which was employed for ROSYFOLIA during the early, developmental and testing period.
- Key result
- Water solubility:
- 70 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7.8
- Conclusions:
- The results in the table show that there is no significant change in the concentrations measured in the stirred solutions after 48 hours, 168 hours and 192 hours. Thus it can be concluded that equilibrium was reached. Thus the results obtained after 48 hours, 168 hours and 192 hours were averaged to give the solubility of GR-50-1408 in ultrapure water. After rounding off:
Solubility of GR-50-1408 in water at 20°C = 70mg/l
Reference
Contact time (h) |
24 |
48 |
168 |
192 |
Average 48-192h |
Concentration (mg/l) |
40.5 |
73.1 |
70.3 |
66.9 |
70 |
All tabulated values represent rounded-off results obtained by calculations based on the exact raw data.
The solubility in ultrapure water was calculated from the analytical concentrations obtained in the analyses shown in the above table. The average results obtained after 48h, 168h and 192 h do not differ by more than 7.5% from the average 48h-192h. It was therefore considered that the saturation was reached.
The results obtained after 24h were not used for the calculation of the water solubility, as it can be concluded that saturation of the aqueous phase was not yet attained.
At the end of the test pH values (pH test stripes) of the solutions in ultrapure water were pH 7.8 on two independent flasks.
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 70 mg/L
- at the temperature of:
- 20 °C
Additional information
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The solubility of GR-50-1408 in ultrapure water was determined according to the OECD Guideline No. 105 (Flask method). The result is: Solubility in water: 70 mg/L at 20°C
This result corresponds to the saturation mass concentration of GR-50-1408 in ultrapure water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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