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Diss Factsheets
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EC number: 225-007-8 | CAS number: 4605-14-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Aug - 27 Aug 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- study protocol is in principle similar to OECD TG 401, limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF-Test: Animals were treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 7 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.
- GLP compliance:
- no
- Test type:
- other: BASF-Test
- Limit test:
- no
Test material
- Reference substance name:
- N,N'-bis(3-aminopropyl)propane-1,3-diamine
- EC Number:
- 225-007-8
- EC Name:
- N,N'-bis(3-aminopropyl)propane-1,3-diamine
- Cas Number:
- 4605-14-5
- Molecular formula:
- C9H24N4
- IUPAC Name:
- N,N'-bis(3-aminopropyl)propane-1,3-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Gassner rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Willi Gassner, Sulzfeld, Germany
- Age at study initiation: young adults
- Weight at study initiation: 142 - 188 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- aqueous emulsion with Traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20%, 10%, 8%, 4%, 2% aqueous emulsion with Traganth - Doses:
- 200, 400, 500, 640, 800, 1000, 1250, 1600 mm3/kg bw (corresponding to 184, 386, 460, 588.8, 736, 920, 1150, 1472 mg/kg bw; calculated using the density of 0.92 g/cm³)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Other examinations performed: clinical signs
- Frequency of observations: several times on the day of application and daily thereafter
- Pathologically investigated: heart, lung, liver, kidney, adrenal gland, stomach, intestine, bladder, genitals, trachea, central nervous system, bone marrow, tumor, blood, urine
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 736 mg/kg bw
- Mortality:
- 1472 mg/kg 10/10 m, 10/10 w
1150 mg/kg 4/10 m, 10/10 w
920 mg/kg 4/10 m, 5/10 w
736 mg/kg 1/10 m, 9/10 w
588.8 mg/kg 0/10 m, 0/10 w
460 mg/kg 0/10 m, 2/10 w
386 mg/kg 0/10 m, 0/10 w
184 mg/kg 0/10 m, 0/10 w - Clinical signs:
- 1472 mg/kg bw: No symptoms on the first day of the trial, the following day rough fur, irregular breathing, apathy. Within 24 hours post applicaion, all animals died
1150 - 460 mg/kg : Huddled together about 10 minutes after application, quiet restrained, shock or irregular breathing and semi-closed eyes. The first six animals died within the first 24 hours,
386 - 184 mg/kg: No symptoms on the first day of the trial, but on the second day rough fur and irregular breathing. - Body weight:
- no data
- Gross pathology:
- Sacrificed animals: Frequently strongly dilated stomachs and sagging intestinal tract. Rot.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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