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Diss Factsheets
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EC number: 928-348-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE CATEGORY APPROACH
Registered substance (as identified in Section 1.1 identification) has similar chemical structure as the others members of the Category "Amino Acid Alkyl Amides, Sodium or Potassium Salts" (the source chemicals).
The category “Amino Acid Alkyl Amides, Sodium or Potassium Salts” has been developed and evaluated to cover the assessment of the intrinsic properties of several similar
substances within the context of REACH Regulation. The Category includes sodium or potassium salts of amino acid alkyl amides, with a carbon chain length range of C6-C16 and an
aminoacidic pool of not selected aminoacids reflecting the natural distributions of aminoacids in various vegetables and cereals.
1. HYPOTHESIS FOR THE CATEGORY APPROACH (ENDPOINT LEVEL)
The Category has been built up considering the common chemical structure of its members. They are UVCB substances and they share the following features:
- they are salts of amino acid alkyl amides
- they are sodium or potassium salts
- the carbon chain length ranges between C6 and C16
- the carbon chain derives from cocoyl or lauroyl fatty acids
- the aminoacidic part of the molecules comes from a pool of aminoacids
- the aminoacids pool reflects the natural distributions of aminoacids in various vegetables and cereals.
Overall, the Category was formed on the hypothesis that substances sharing this common chemical structure can be considered analogues and can share intrinsic properties too. No
trends in properties is expected, except for those physicochemical properties depending on the carbon chain length.
2. CATEGORY APPROACH JUSTIFICATION
These substances share (i) eye damage and (ii) the absence of significant systemic toxicity. - Key result
- Boiling pt.:
- > 100 °C
- Decomposition:
- no
- Remarks on result:
- other: Boiling point values are available for category members: (i) 105°C, (ii) 106.5°C.
- Remarks:
- Boiling point values are available for category members: (i) 105°C, (ii) 106.5°C.
- Conclusions:
- A collection of the boiling point values is available for category members. Considering these values the registered substance has a boiling point higher than 100°C.
- Executive summary:
The category “Amino Acid Alkyl Amides, Sodium or Potassium Salts” was formed on the hypothesis that substances sharing common chemical structure can be considered analogues and can share intrinsic properties too.
Based on this assumption, this property may be assessed using available data for the category members.
The category has been assessed for members characterized by:
- sodium or potassium salts
- the carbon chain length ranges between C6 and C16
- the aminoacids pool reflects the natural distributions of aminoacids in various vegetables and cereals.
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 Dec. 2007 - 20 Feb. 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD n° 103 and GLP study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Deviations:
- no
- Principles of method if other than guideline:
- The test item sample and reference material are both maintained at the temperature predetermined by the program even during a thermal event in the sample. The amount of energy which has to be supplied to the sample to maintain zero temperature differential between the test item sample and the reference material is the experimental parameter displayed as the ordinate of the thermal analysis curve. The rate of energy absorption by the sample is proportional to the specific heat of the sample.
Any transition accompanied by a change in specific heat produces a discontinuity in the power signal. Boiling of the test item will be characterized by an endothermic enthalpy change that gives a peak whose area is proportional to the total enthalpy change. The boiling temperature depends on the atmospheric pressure so boiling temperature will be corrected if necessary. - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- TEST ITEM
Identification LCE07102
Identification of the flask LCE07102, Req Nr: 24/07/00262/05,
Net: 2,500 L
Batch LCE07102
Expiry date Not provided
Supplier SEPPIC
Appearance Yellow liquid
Packaging 2 White opaque plastic flasks
Quantity received 2 x 1 Kg
Date of the reception December 12, 2007
Storage In darkness at room temperature
Identification number for the study 07-157
REFERENCE ITEM
Identification 1,2 Propanediol 99%
Supplier ACROS
Batch A0249565
Expiry date of the reference item December 03, 2008
Last validation of the test December 05, 2007
Periodicity of validation (in months) 12
Results 187.0 ± 0.5 °C
Conformity Yes
Apparatus
Analyser DSC 131 The analyzer is connected to a computer using the Setsoft 2000 program
Balance
Barometer - Key result
- Boiling pt.:
- ca. 106.5 °C
- Atm. press.:
- >= 98.3 - <= 98.7 kPa
- Decomposition:
- no
- Conclusions:
- The boiling point was calculated: 106.5 +/- 0.5 °C at 98.5 +/- 0.2 kPa.
- Executive summary:
BOILING POINT (DSC METHOD)
In compliance with Commission Directive 92/69/EEC A2 method (1992) and OECD Guideline No. 103 (1995)
AMENDMENTS
No amendment to the study plan was requested.
DEVIATIONS
No incident, which could have affected the quality or the interpretation of the results obtained, was observed.
RESULTS
The mean corrected boiling point of the test item was: 106.5 ± 0.5 °C.
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January-March 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: experimental study which follows standard guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling point/boiling range)
- GLP compliance:
- no
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- Name of the test material (as cited in the study report): PROTEOL APL
Lots/batches: LR10709-LR 10747-LR10749 - Key result
- Boiling pt.:
- 105 °C
- Atm. press.:
- 1 atm
- Decomposition:
- no
- Conclusions:
- The mean boiling point of the test item was (on 2 assays on 3 batches): 105°C (+/- 2°C)
- Executive summary:
The mean boiling point of the test item was (on 2 assays on 3 batches): 105°C (+/- 2°C)
Referenceopen allclose all
Description of key information
Category members (Amino Acid Alkyl Amides, Sodium or Potassium Salts) have boiling point values higher than 100°C.
Key value for chemical safety assessment
Additional information
A collection of the boiling point values is available for category members. All found values are listed below.
EC number |
Boiling point (°C) |
S1 - EC: 918-984-3 |
105°C |
S2 - EC: 927-837-2 |
106.5°C |
Overall, registered substance has boiling point higher than 100°C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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