Registration Dossier
Registration Dossier
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EC number: 479-150-8 | CAS number: 7784-22-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 479-150-8
- EC Name:
- -
- Cas Number:
- 7784-22-7
- Molecular formula:
- AlH6O6P3
- IUPAC Name:
- Phosphinic acid, aluminum salt (3:1)
- Test material form:
- solid: particulate/powder
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 tissue fraction prepared from livers of five young Sprague-Dawley rats treated with phenobarbital and betanaphthoflavone.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 6.25 ... 250 µg/plate
Concentration range in the main test (without metabolic activation): 6.25 ... 250 µg/plate - Vehicle / solvent:
- Solvent: Water/phosphoric acid in the ratio 100:5 (v/v)
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 250 µg/plate)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 250 µg/plate)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 250 µg/plate)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 250 µg/plate)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- Marked increases in revertant number were obtained in positive controls.
- Remarks on result:
- other: preliminary test
Applicant's summary and conclusion
- Conclusions:
- Aluminium Hypophosphite does not induce gene mutation in a bacterial test.
- Executive summary:
Aluminium Hypophosphite was tested according to OECD Guideline 471 (Ames test) in 5 strains, with and without S9 activation.
The test item was tested at concentration lower than cytotoxicity levels, measured in each strain. None of the tested concentrations induced gene mutation.
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