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EC number: 203-319-5 | CAS number: 105-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The experiments were carried out between 10 December 1985 and 20 December 1985.
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- AS DIXD is a known hydrolysis degradant of AS100, an AS100 study is being used as read-across for this shorter chain sulphide structural analogue.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Di-isopropyl xanthogen polysulphide
- IUPAC Name:
- Di-isopropyl xanthogen polysulphide
- Test material form:
- other: liquid batch
- Details on test material:
- Sponsor's identification : Robac AS100
Description : liquid
Batch number : 246041130005
Sample dated 12th February 2013
Constituent 1
Method
- Target gene:
- Histidine for Salmonella.
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- Not applicable
- Species / strain / cell type:
- S. typhimurium TA 1538
- Details on mammalian cell type (if applicable):
- Not applicable.
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254 induced rat liver, S9 mix
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: hexane
Controlsopen allclose all
- Untreated negative controls:
- yes
- Remarks:
- Spontaneous mutation rates
- Negative solvent / vehicle controls:
- yes
- Remarks:
- hexane
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene (AA)
- Untreated negative controls:
- yes
- Remarks:
- Spntaneous mutation rates
- Negative solvent / vehicle controls:
- yes
- Remarks:
- hexane
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 2-nitrofluorene (NF), 9-aminoacridine (9-AC), N--ethyl-N''-nitro-Nnitrosoguanidine (ENNG)
- Remarks:
- Used without S9 mix
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Exposure duration: 72 hrs
NUMBER OF REPLICATIONS: Triplicate plating.
DETERMINATION OF CYTOTOXICITY
- Method: Any toxic effects of the test substance are detected by a substantial reduction in revertant colony counts or by the absence of a complete background bacterial lawn. - Evaluation criteria:
- The mean number of revertant colonies for all treatment groups is compared with those obtained for negative and positive control groups. The effect of metabolic activation is assessed by comparing the results obtained both in the presence and absence of the liver microsomal fraction for each treatment group.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- The revertant colony counts for DIXT obtained in the dose range finding test are shown in Table 1 (see attached background material). DIXT was not toxic towards the tester strains. Therefore 5000 µg/plate was chosen as the top dose level in the mutation tests.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
See attached background material for:
Table 1: Dose range finding test on DIXT - revertant colony numbers obtained with bacterial strains TA 1535, TA 1537, TA 1538, TA 98 and TA100
Table 2: Test 1; DIXT - revertant colony counts obtained per plate using bacterial strains TA 1535, TA 1537, TA 1538, TA 98 and TA100
Table 3: Test 1; Mutability and sterility tests with bacterial strains TA 1535, TA 1537, TA 1538, TA 98 and TA100
Table 4: Test 2; DIXT - revertant colony counts obtained per plate using bacterial strains TA 1535, TA 1537, TA 1538, TA 98 and TA100
Table 5: Test 2; Mutability and sterility tests with bacterial strains TA 1535, TA 1537, TA 1538, TA 98 and TA100
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
It is concluded that no evidence of mutagenic potential of DIXT was obtained in this bacterial test system at the dose levels used. - Executive summary:
Introduction.
The object of the study was to assess the mutagenic potential of the test material in a bacterial system, following a test method based on OECD Guideline No. 471: Genetic Toxicology: Salmonella typhiumurium, Reverse Mutation Assay.
Methods.
Salmonella typhimuriumstrains TA 1535, TA 1537, TA 1538, TA 98 and TA 100 were used in the study.
The dose levels used were 5000, 500, 50 and 5 µg/plate in a dose range finding test, and 5000, 1500, 500, 150 and 50 µg/plate in the subsequent mutation tests.
Each dose level was tested in triplicate, both with and without metabolic activation (S9 mix).
Results.
In the dose range finding test, DIXT was not toxic towards the tester strains. Therefore 5000 µg/plate was chosen as the top dose level in the mutation tests.
No substantial increases in revertant colony numbers of any of the five tester strains were observed following treatment with DIXT at any dose level, either in the presence or absence of metabolic activation (S9 mix).
Conclusion.
It is concluded that no evidence of mutagenic potential of DIXT was obtained in this bacterial test system at th dose levels used.
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