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Diss Factsheets
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EC number: 203-319-5 | CAS number: 105-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of study:
- intracutaneous test
- Justification for non-LLNA method:
- Testing was completed in the 1960's before the LLNA method was available.
Test material
- Reference substance name:
- di-isopropyl xanthogen disulphide (DIXD)
- IUPAC Name:
- di-isopropyl xanthogen disulphide (DIXD)
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: 1:1 acetone-dioxane in 13% guinea pig fat
- Concentration / amount:
- 0.1ml of the 0.5% solution
- Day(s)/duration:
- 14 and 21 days
- Adequacy of induction:
- highest concentration used causing mild-to-moderate skin irritation and well-tolerated systemically
Challengeopen allclose all
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- other: 1:1 acetone-dioxane containing 13% guinea pig fat (f.a.d.)
- Remarks:
- 1, 1, 2 and 6 appplications were made over a 3-week period
- Concentration / amount:
- 1 drop of test solution was diluted in 1:1 acetone-dioxane in 13% guinea pig fat (f.a.d.)
- Day(s)/duration:
- 21 days
- Adequacy of challenge:
- not specified
- No.:
- #2
- Route:
- epicutaneous, open
- Vehicle:
- other: 1:1 acetone-dioxane containing 13% guinea pig fat (f.a.d.)
- Concentration / amount:
- Following a 2 week rest period. 0.5% of f.a.d. was applied to intact skin and 0.2% of f.a.d. was applied to abraded skin, respectively.
- Day(s)/duration:
- 1 day
- Adequacy of challenge:
- not specified
- No.:
- #3
- Route:
- intradermal
- Vehicle:
- other: Test material in propylene glycol
- Concentration / amount:
- Injections of 0.1ml of a 0.5% solution were injected in the sacral region.
- Day(s)/duration:
- 1 day
- Adequacy of challenge:
- not specified
- No.:
- #4
- Route:
- epicutaneous, open
- Vehicle:
- other: 1:1 acetone-dioxane containing 13% guinea pig fat (f.a.d.)
- Concentration / amount:
- Follwing 2 and 3 weeks later 0.5% of f.a.d. soluiton was applied to inact skin and 0.2% of f.a.d. solution was applied to abraded skin, respectively.
- Day(s)/duration:
- 1 day
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 10 each
- Details on study design:
- For sensitization, nine applications to abraded skin were made during a 2 week period with 0.05, 0.1, 0.2 and 0.5% solutions of f.a.d (1, 1, 2 and 6 aplications, respectively). Following a two-week rest period, a challenge test was done which consisted of applying a 0.5% and 0.2% f.a.d. solution of the test material to intact and abraded skin, respectively. In addition, another group of 10 male guinea pigs were tested for skin sensitization by giving each of them intradermal injection of 0.1ml of a 0.5% solution of the test material in propylene glycol in the sacral region; these animals were given challenge tests two and three weeks later by aplying a 0.5% and 0.2% f.a.d. solution of the test matrial to intact and abraded skin, respectively.
- Challenge controls:
- none
- Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- none
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 2nd reading
- Group:
- test chemical
- Dose level:
- 0.1ml of a 0.5% f.a.d. solution
- No. with + reactions:
- 9
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- positive indication of skin sensitisation
- Key result
- Reading:
- 2nd reading
- Group:
- test chemical
- Dose level:
- 0.1ml of a 0.5% f.a.d. solution
- No. with + reactions:
- 7
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- positive indication of skin sensitisation
- Key result
- Reading:
- 1st reading
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 1
- Clinical observations:
- None
- Key result
- Reading:
- 1st reading
- Group:
- positive control
- Dose level:
- 0.1 ml of a 0.5% f.a.d. solution
- No. with + reactions:
- 1
- Total no. in group:
- 1
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- Shown to be a strong skin sensitizer
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