Registration Dossier
Registration Dossier
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EC number: 263-196-9 | CAS number: 61791-64-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
- Version / remarks:
- Assumed from details given in the review. Actual method used was not quoted
- GLP compliance:
- not specified
- Remarks:
- No details given in the review article
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Amides, coco, N,N-bis(hydroxyethyl)
- EC Number:
- 271-657-0
- EC Name:
- Amides, coco, N,N-bis(hydroxyethyl)
- Cas Number:
- 68603-42-9
- Molecular formula:
- C16H33NO
- IUPAC Name:
- N,N-Bis(2-hydroxyethyl)dodecanamide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Applied to intact and abraided skin
- Duration of exposure:
- 24 hours
- Doses:
- 2g/kg
- No. of animals per sex per dose:
- 3
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other:
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal toxicity of cocamide DEA was evaluated using albino rabbits. Cocamide DEA were applied to intact and abraded skin for 24 h using occlusive patches. None of the animals died, and the LD50 was >2 g/kg.
Cocamide DEA is a mixture of ethanolamides of coconut acid. The chemistry of the amides is considered to be sufficiently close to the cocamines to be a suitable surrogate for read-across in the absence of any animal test data for the substance under registration.
Other similar cocamide species, such as lauramide DEA, were also tested in this acute dermal toxicity study and also found to be non-toxic
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