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Diss Factsheets
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EC number: 269-102-2 | CAS number: 68187-50-8 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77498.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- adopted 2001-12-17
- Deviations:
- yes
- Remarks:
- No CAS, no justification for using males; age of rats not given; humidity (80%); rats not exposed in stepwise manner;it was only stated that animals were regular observed during first day, no details on food and water quality
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Iron cobalt chromite black spinel
- EC Number:
- 269-060-5
- EC Name:
- Iron cobalt chromite black spinel
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: L-271R
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source of test animals: provided by an authorized supplier
- Age at study initiation: young and healthy
- Weight at study initiation: males: 140 - 160 g; females: 201 - 209 g
- Fasting period before study: animals fasten during the previous night; after 3 hours of administration, feeding was restored.
- Housing: groups of three; Makrolon cages (48 x 27x 20 cm), brand Tecniplast, with wooden bedding; cleaning by means of changing wooden bedding
- Diet (ad libitum): diet for experimental rats, provided by an authorized provider
- Water (ad libitum): tap water
- Acclimation period: 7 days
At arrival at the Unit, rats went through a health control.
ENVIRONMENTAL CONDITIONS
- Temperature: 21 °C (+/- 2°C)
- Relative humidity: 55% (+/- 25%)
- Air: renewed 15 times per hour and prefiltered at 5 µm
- Photoperiod (hrs dark / hrs light): 12/12
No further information on the test animals was stated.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2 mL of the diluted sample per 100 grams of alive weight
DOSAGE PREPARATION: 2000 mg of a sample were diluted in 20 mL of distilled apirogenic water. Sample was vigorously stirred before administration.
CLASS METHOD
- Rationale for the selection of the starting dose: the available information suggested that the sample is little toxic and the limit test was performed.
No further information on the oral exposure was stated. - Doses:
- 2000 mg/kg of alive weight
- No. of animals per sex per dose:
- 3 males / 3 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: individual weight control was performed at the beginning of the study, before administration, after 7 days of administration and at the end of the study or in case of death, right after death. A general clinical examination was performed every working day during which modifications were observed and noted, among others: skin, hair, eyes, mucosity, respiratory track, circulatory system, central and autonomous nervous system, motion activity and behavioural lines of action. With special care for: shaking, convulsions, salivation, diarrhea, lethargy, sleep and coma.
During the first day regular observations were performed and the following days the animals were observed at least once daily for 14 days.
The observed signs of toxicity were observed at the moment of appearance and also the time of recovery.
- Necropsy of survivors performed: yes; after the study, the surviving animals were sacrificed by means of a humanitarian method (cervical dislocation). All the animals in the study were subject to macroscopic necropsy. Macroscopic pathology were noted for each animal. - Statistics:
- not applicable
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived until the end of the 14 days of observation.
- Clinical signs:
- other: Neither abnormal effects nor any toxicity signs that could be attributed to the test item were observed.
- Gross pathology:
- There were no relevant macroscopic changes observed in any of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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