Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-190-2 | CAS number: 92-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.-23.03.1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Register Vol 38, no 187, S. 27019, 1973
- GLP compliance:
- no
- Remarks:
- conducted prior to GLP guideline implementation
Test material
- Reference substance name:
- 3-hydroxy-4'-methoxy-2-naphthanilide
- EC Number:
- 202-190-2
- EC Name:
- 3-hydroxy-4'-methoxy-2-naphthanilide
- Cas Number:
- 92-79-5
- Molecular formula:
- C18H15NO3
- IUPAC Name:
- 3-hydroxy-4'-methoxy-2-naphthanilide
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG breeding colony
- Strain: SPF-Albino-Himalayan, Hoe HIMK(SPFWiga)
- Housing: single cage
- Diet: ERKA 8300, ad libitum
- Water: tap water, ad libitum
Test system
- Vehicle:
- other: propandiol 1,2
- Controls:
- other: untreated right eyes served as control
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 72 h after beginning of treatment
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- One time application of the substance to the conjunctival sac of the left eye of each animal, the right eye served as control respectively
- Washing: washing with physiological saline 24 h after administration
- After the 24 h readings a droplet of a 0.01 % solution of fluorescein sodium was applied for the 48 and 72 h readings
- The eyes are examined and the grade of ocular reaction is recorded at 1, 24, 48, and 72 hours after administration
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 28
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Remarks:
- according to the FDA scoring system
- Irritant / corrosive response data:
- In view of the shortened observation period and the slightness of effects a full recovery is expected in the case of a prolonged observation period of 21 days according to effective guidelines.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification acc. to (EC) 1272/2008: not irritating
This conclusion is legitimate since the test conditions are basically in accordance with todays standard methods regarding dosing, exposure duration, scoring system and reading time points. - Executive summary:
Test material was subject to a test of eye irritancy according to FDA Guideline. 100 mg of substance were applied to one eye of six rabbits. Mean values of the 24, 48 and 72 h readings after beginning of treatment were calculated for each animal. Only slight effects (conjunctival redness mean score: 1.4; chemosis mean score: 0.8; corneal opacity mean score: 0.8; iridial effects mean score: 0, below
the threshold for classification were determined.
All effects are expected to be fully reversible.
Based on these findings the test material was judged not to be irritating to the eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)