Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-190-2 | CAS number: 92-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Appearance / physical state / colour
Administrative data
- Endpoint:
- appearance / physical state / colour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: observation made during recent daphnia testing
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017/07/26-2017/11/12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: analytical samples taken at 0 hours (initial value) and 48 hours from aged test solutions
- Fortified samples: stock solution of the test item (1000 mg/L, purity not considered) was prepared in acetonitrile. Further stock solutions (1620 mg/L and 2130 mg/L, purity not considered) were prepared in acetone. A dilution (10 mg/L) was prepared from the 2130 mg/L stock solution. A further dilution (10 mg/L) was prepared in acetonitrile from the 1620 mg/L stock solution. The dilutions (10 mg/L) were used for fortification of 0.0300 mg/L recovery samples. For 16.0 mg/L recovery samples the stock solution 1000 mg/L was used.
- Sample storage (before test): all samples were stored deep frozen until they were transferred to the analytical laboratory - Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: straus, clone 5
- Feeding during test: no feeding during test
- Feeding of culture (before test): three times a week with single cell green algae
- Main test: freshly hatched daphnids less than 24 hours old were used - Test type:
- static
- Water media type:
- other: Elendt M4
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 232 mg/L as CaCO3
- Test temperature:
- 20.0 – 21.8 °C
- pH:
- 7.62 – 7.98
- Dissolved oxygen:
- ≥ 7.2 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 100, 31.3, 9.77, 3.05, 0.954 mg/L and control
Test item loading rates (geometric mean measured): 1.80 mg/L (corresponding to 100), the other values were only monitored (not reported) and for the control it was not determined - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers
- Material, size, headspace, fill volume: 100 mL capacity filled with 50mL of test solution
- No. of organisms: 20 daphnids per test item loading rates (4 replicates of 5 animals each)
- No. of treatment groups: 6 (5 dose rates of the test item and a control)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M4
- Culture medium different from test medium: same as Elendt M4
OTHER TEST CONDITIONS
- Exposure to light: none
EFFECT PARAMETERS MEASURED: Immobilisation
RANGE-FINDING STUDY
- Test concentrations: control, 100, 10, 1 and 0.1mg/L
- Sampling points : after 24h and 48h of exposure
- Results used to determine the conditions for the definitive study:
- After 24 hours of exposure no immobilisation above the allowed control immobilisation was observed in the control and up to and including 100 mg/L.
- After 48 hours of exposure no immobilisation was observed in the control and up to and including 10.0 mg/L. 15 % immobilisation was observed at the highest test item loading rate of 100 mg/L. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate, tested at 1.00 and 2.00 mg/L with 20 test organisms per test concentration, at around the same time period as the study
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Test concencentrations: 1 and 2 mg/L (20 organisms per test concentration)
- Relevant effect levels: the results indicate an EC50 (24h) of the reference substance below 1mg/L. The reuslts are in accordance with the requirements of the OECD guideline 202. - Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hour EC50 for Daphnia magna is > 1.8 mg/L (measured, geom. mean).
- Executive summary:
The short-term toxicity to Daphnia magna was determined according to OECD 202 guideline with no deviations. The study was conducted under static conditions. The daphnids were exposed over a period of 48 hours to different nominal concentrations of 100, 31.3, 9.77, 3.05, 0.954 mg/L and a control. The measured concentration is 1.80 mg/L (corresponding to 100), the other values were only monitored (not reported) and for the control it was not determined.
The validity criteria were fulfilled.
The EC50 value was determined to be > 1.80 mg/L (measured, geom. mean).
Summary of biological results:
a) Results of the main test, 24h values
|
nominal test item loading rate [mg/L] |
|||||
|
Control |
0.954 |
3.05 |
9.77 |
31.3 |
100 |
immobilised daphnids after 24 h |
||||||
Group 1 |
0 |
2 |
0 |
0 |
0 |
0 |
Group 2 |
0 |
0 |
0 |
0 |
1 |
0 |
Group 3 |
0 |
0 |
1 |
0 |
0 |
0 |
Group 4 |
0 |
0 |
0 |
0 |
0 |
0 |
Σ |
0 |
2 |
1 |
0 |
1 |
0 |
% |
0 |
10 |
5 |
0 |
5 |
0 |
b) Results of the main test, 48h values
|
nominal test item loading rate [mg/L] |
|||||
|
Control |
0.954 |
3.05 |
9.77 |
31.3 |
100 |
immobilised daphnids after 48 h |
||||||
Group 1 |
0 |
2 |
0 |
0 |
0 |
0 |
Group 2 |
0 |
0 |
0 |
0 |
2 |
0 |
Group 3 |
0 |
0 |
1 |
0 |
0 |
0 |
Group 4 |
0 |
0 |
0 |
0 |
0 |
0 |
Σ |
0 |
2 |
1 |
0 |
2 |
0 |
% |
0 |
10 |
5 |
0 |
10 |
0 |
Determined concentration of test substance:
Test item loading rate |
Test item |
Sampling |
Test item found |
Test item concentration |
||
nominal [mg/L] |
nominal [mg/L] |
[h] |
[mg/L] |
% of nominal |
measured [mg/L]* |
|
Control |
0 |
0 fresh |
n.d. |
- |
- |
|
48 aged |
n.d. |
- |
||||
100 |
|
0 fresh |
15.3 |
15 |
1.80 |
|
48 aged |
0.215 |
0.215 |
* based on geometric mean of measured concentrations
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no guideline followed, the results are obtained from observations made during a recent study on Algae testing of the substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-hydroxy-4'-methoxy-2-naphthanilide
- EC Number:
- 202-190-2
- EC Name:
- 3-hydroxy-4'-methoxy-2-naphthanilide
- Cas Number:
- 92-79-5
- Molecular formula:
- C18H15NO3
- IUPAC Name:
- 3-hydroxy-4'-methoxy-2-naphthanilide
- Test material form:
- solid
- Details on test material:
- - Batch number: 1283282001
- Purity: 98.8%
- Appearance/colour: solid/yellow-brown
- Expiry date: 30 April 2019
Constituent 1
Results and discussion
- Physical state at 20°C and 1013 hPa:
- solid
Form / colour / odour
- Key result
- Form:
- solid
- Colour:
- yellow-brown
- Substance type:
- organic
Applicant's summary and conclusion
- Conclusions:
- The test substance is a yellow-brown solid product.
- Executive summary:
The results are obtained from observations made during a recent study on Algae testing of the substance
The substance is a yellow brown solid product.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.