Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Five rats were exposed to an vapour-air mixture for 4h, 14 days observation period following administration.
GLP compliance:
no
Remarks:
study performed prior to implementation of GLP
Test type:
other: Please refer to principles of method if other than guideline
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N-methyl-N-vinylacetamide
EC Number:
221-698-5
EC Name:
N-methyl-N-vinylacetamide
Cas Number:
3195-78-6
Molecular formula:
C5H9NO
IUPAC Name:
N-ethenyl-N-methylacetamide

Test animals

Species:
rat
Strain:
other: albino
Sex:
male
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
The vapour-air mixture is generated by passing 2.5 litres/minute of dried air at room temperature through a fritted glas disc immersed to a depth of at least one inch in approximately 50 mL if the test chemical contained in a gas-washing bottle.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
4000 ppm
No. of animals per sex per dose:
5
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 4 000 ppm
Based on:
test mat.
Remarks on result:
other: 4000 ppm corresponding to approximately 16207 mg/m³
Mortality:
0/5 animals died

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met