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EC number: 235-125-1
CAS number: 12070-14-3
Table 1: Results of bio-elution tests
Weight Used (g)
µg Zirconium /
% Zirconium Release/ Zirconium Content
Simulated Gastric Fluid
Simulated Interstitial Fluid
Simulated Lysosomal Fluid
This report measured bioaccessibility of Zirconium carbide as a
surrogate for bioavailability. Thus, the soluble zirconium was measured
by using EPA Method #200.8 (ICP/MS) after incubation of Zirconium
carbide in different simulated body fluids (simulated gastric fluid,
simulated interstitial fluid, simulated lysosomal fluid, and artificial
perspiration). Results were reported as µg Zr/g sample, % Zr release/Zr
content. The release of zirconium ions from Zirconium carbide was very
low in artificial body fluids. The results of the study are summarized
in the table below:
The release of zirconium ions from Zirconium carbide was very low in
artificial body fluids. For simulated gastric fluid, simulated
interstitial fluid and artificial perspiration no release of zirconium
ions was observed as the results were below the detection limit of the
method. Only in simulated lysosomal fluid 0.005% zirconium ions were
released within 24 hours from Zirconium carbide.
The bioaccessibility of Zirconium carbide as a surrogate for
bioavailability was measured. For this purpose soluble zirconium ions
were measured using the EPA method #200.8 (ICP/MS) after incubation of
Zirconium carbide in different simulated body fluids (simulated gastric
fluid, simulated interstitial fluid, simulated lysosomal fluid and
In summary, in all body fluids the release of zirconium ions was
below the detection limit of the methodology used, except for the
simulated lysosomal body fluid, in which the release of zirconium was
measured with 0.005%. Based on the results, the bioavailability of
Zirconium carbide can be considered to be very low for all routes of
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