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EC number: 272-554-3
CAS number: 68877-27-0
In an eye irritation/corrosion
well-performed study according to Directive 92/69/EEC B.5 and OECD
guideline 405, three male New Zealand White rabbits were treated by
instillation of approximately 64 mg of zinc oxide (a volume of about 0.1
ml) into the conjuctival sac of one eye. The other eye remained
untreated and served as control. After 24 hours, both eyes of two
animals were rinsed with water. The eyes were examined at 1, 24, 48 and
72 hours after instillation. No symptoms of systemic toxicity were
observed and no mortality occurred. Slight iridial irritation (grade 1)
was observed in one animal, at 1 hour only. Slight irritation of the
conjuctivae (grade 1-2) was seen as redness (mean scores over 24-72
hours 0.7, 1 and 1), which had completely resolved at 72 hours in all
animals. Chemosis (grade 2) and discharge (grade 1) were also observed
in all animals, but at 1 hour only. No corneal opacity or epithelial
damage was observed in any of the animals.
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