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EC number: 272-554-3
CAS number: 68877-27-0
A study was conducted to evaluate the skin
irritation potential of zinc oxide in New Zealand White rabbits by both
open and occlusive patch methods.
In open patch test, 0.5 mL of 20 % w/v zinc
oxide suspension in 0.1 % Tween 80 or vehicle was applied to clipped
sites (5 cm2) of groups of four animals for 5 d. Skin sites
were observed during and after 5 d exposure period. Animals were killed
24 h after the fifth daily treatment.
In occlusive patch test, groups of four
animals were treated similarly to open patch test, but the test
suspension or vehicle was applied to the skin using occlusive dressing
for 3 d. After 3 d, dressings were removed and skin sites evaluated for
irritancy. Two rabbits were killed at this stage. The remaining animals
were redressed with freshly impregnated gauzes and then re-examined and
killed after a further 2 d.
In both tests, representative samples of
each test and control skin site of killed animals were analysed
histologically and stained with morin dye to study epidermal keratin
binding of zinc.
No obvious reactions were observed in both
control and treatment groups in any of the performed tests after 5 d
exposure. No evidence of damage was observed upon histological
examination. No morin fluorescence was observed in skin sections.
Based on these results, 20 % w/v zinc oxide
was found to be non-irritating to rabbit skin.
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