Registration Dossier

Administrative data

Description of key information

Skin Sensitization: Aqueous dispersion of TNS administered OECD 429. No sensitization. Not classified as a skin sensitizer. Reliability = 1

Respiratory Sensitization: Not specifically tested for this endpoint. However, no adverse respiratory tissue effects observed in acute or repeated inhalation studies. Neither structurally nor mechanistically (chemically) related to any known respiratory sensitisers. Not classified as a respiratory sensitizer.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The aqueous dispersion of TNS (~20% solids and~80% water) was administered directly in the local lymph node assay (LLNA) without correction for active ingredient since the product does not exist as TNS alone and is always transported and used as the aqueous dispersion. TNS was not a sensitiser in the murine local lymph node assay and therefore is not considered to have potential to be a skin sensitiser.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

TNS is neither structurally nor mechanistically (chemically) related to any known respiratory sensitisers and therefore is not expected to be a respiratory sensitiser.

Justification for classification or non-classification

TNS is not classified for sensitization based on the lack of a response in the murine local lymph node assay. It is also not classified as a respiratory sensitizer due to a lack of any data for this endpoint, and any structural similarity with known respiratory sensitizers. Therefore, no sensitization classification is proposed according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.