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EC number: 411-490-4 | CAS number: 7027-11-4 ISOPHORONENITRILE, IPN
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The derived LD 50 value for acute oral toxicity is 178 mg/kg bw (Hüls, 1985) for Isophorone nitrile. Thus the substance is regarded and classified as toxic if swallowed. Because of a LD50 value for acute dermal toxicity of more than 2000 mg/kg b.w in rabbits (Asta, 1990), the test item showed very low dermal toxicity under conditions the conducted study. According to the outcome of an acute inhalation study with rats (RCC, 1999; LC50 1.34 mg/l air ) Isophorone nitril is regarded and classified as harmful by inhalation.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 178 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 1 340 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Studies in animals:
Oral exposure:
Two oral acute toxicty studies in rats were conducted with the test item Isophorone nitrile. The derived LD 50 values are 178 mg/kg bw (Hüls, 1985) and 272 mg/kg (Asta, 1990). Because of identical reliability codes and because of worst case considerations the study with the lowest LD 50 value (Hüls, 1985) was choosen to be the key study. According to the outcome of the (key) study Isophorone nitrile is regarded and classified as toxic if swallowed.
Dermal exposure:
In a dermal acute toxicity test the determined LD50 value for male and female rabbits was above 2000 mg/kg b.w. (Asta, 1990). Thus, the test item showed very low dermal toxicity under conditions this study.
Inhalative exposure:
An acute inhalation study was conducted in rats (RCC, 1999). The LC 50 of isophorone nitrile for acute inalation toxicity (4 h) was estimated to be 1.34 mg/l air in rats. Because of this result the test item Isophorone nitril is regarded and classified as harmful by inhalation.
Justification for classification or non-classification
The substance 3-cyano-3,5,5-trimethylcyclohexanone (Isophorone nitrile) is classified according to the criteria of EC Directive 67/548/EEC as follows: "Toxic if swallowed" (T, R 25) and "Harmful by inhalation" (Xn, R 20)
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