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EC number: 500-209-1 | CAS number: 68412-54-4 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Excretion of certain polyethylene glycol ether adducts of nonylphenol by the rat
- Author:
- Knaak JB, Eldrige Jane M and Sullivan LJ
- Year:
- 1 966
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 9:331-340
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- The study was conducted to evaluate the excretion of the test substances in urine, feces and CO2 and analysed using chromatographic methods.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- NPE-9
- IUPAC Name:
- NPE-9
- Details on test material:
- - Name of test material (as cited in study report): Test substance 1: Nonylphenol-14C (NP-14C ); test substance 2: Nonylphenol-14C TP-9 (NP-14C TP-9); test substance 3: Isolated ethylene-14C oxide TP-9 fractions representing adduct numbers of 7, 10, 12, and 15
- Radiochemical purity (if radiolabelling): Yes
- Specific activity (if radiolabelling): Test substance 1: 1.0 µc/mg; test substance 2: 0.3 µc/mg; test substance 3: Not reported
- Locations of the label (if radiolabelling): Test substance 1 and 2: at the carbon in the NP group; test substance 3: at the carbon in ethylene oxide group
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- other: carworth farms-elias stock
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Body weight: 150 g
No further details reported.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Propylene glycol for test substance 1 and water for test substance 1 and 2
- Details on exposure:
- Dosing solution details:
- 1 mg of test substance 1 was administered orally or intraperitoneally to 150 g male rats in 500 mg of propylene glycol (i.e., equivalent to 6.7 mg/kg bw) .
- 10 mg of test substance 2 and 3 were administered to 150 g male rats in 990 mg of water (i.e., equivalent to 67 mg/kg bw). - Duration and frequency of treatment / exposure:
- Single dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
- Test substance 1: 6.7 mg/kg bw
- Test substance 2 and 3: 67 mg/kg bw
- No. of animals per sex per dose / concentration:
- 4
- Control animals:
- not specified
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Excretion and metabolites characterisation)
- Tissues and body fluids sampled: Urine, faeces, cage washes, caracasess and/or CO2
- Time and frequency of sampling: Daily for 14C in urine and faeces over a 7-day period and for 14C in CO2 over a 4-day period for all the three samples; at termination for 14C in carcasses for test substance 3.
- Method type(s) for identification: Gas chromatography for nonylphenol; thin layer chromatography for TP-9, ion-exhange chromatography for the metabolites
Results and discussion
Main ADME resultsopen allclose all
- Type:
- excretion
- Results:
- 20% of the test substance 1 and 2 was excreted in urine, 78% in faeces (within 7 d period) and none in CO2 (within 4 d period)
- Type:
- excretion
- Results:
- 85, 90, 88 and 85% was excreted in urine and feces while 3.3, 1.2, 0.78, 0.20 and 1.2% was excreted in 14CO2 for 7-, 10-, 12-, and 15- mole adducts of test substance 3 respectively.
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- -Test substance 1 (i.e., 14C-NP): 20% in urine, 78% in faeces (over 7 d period) and none in CO2 (over 4 d period)
-Test substance 2 (i.e., NP-14C TP-9): 20% in urine, 78% in faeces (over 7 d period) and none in CO2 (over 4 d period)
-Test substance 3 (i.e., the isolated ethylene 14C oxide TP-9 fractions representing adduct numbers of 7, 10, 12 and 15): 85, 90, 88 and 85% was excreted in urine and feces while 3.3, 1.2, 0.78, 0.20 and 1.2% was excreted in 14CO2 for 7-, 10-, 12-, and 15- mole adducts respectively (refer to attached document for details).
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The major urinary metabolites were found to be mono- and dicarboxylic acids of polyethylene glycol and the glucuronic acid conjugates of nonylphenol by ion-exchange chromatographic.
Any other information on results incl. tables
Other findings:
The carcasses of animals administered test substance 2 and 3 were examined for 14C residues and were found to be free of detectable radioactivity.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
Under the condition of the study, the rat excreted both 14C-NP and NP-14C TP-9 as 20% in urine and 78% in feces and none in CO2 indicating an oral absorption of about 20%. Further, the 12- and 15-mole adducts of isolated ethylene 14C oxide TP-9 fractions were excreted to a greater extent in the feces than the 7- and 10-mole adducts and the reverse situation occurred in urine. - Executive summary:
A study was conducted to evaluate the excretion of NP-14C TP-9, 14C-NP and the isolated ethylene 14C oxide TP-9 fractions representing adduct numbers of 7, 10, 12 and 15 in male rats.
1 mg of 14C-NP was administered orally or intraperitoneally to 150 g weighing male rats in 500 mg of propylene glycol (i.e., equivalent to 6.7 mg/kg bw). While, 10 mg of NP-14C TP-9 and isolated ethylene 14C oxide TP-9 fractions were administered to 150 g male rats in 990 mg of water (i.e., equivalent to 67 mg/kg bw). Then the daily urine and fecal samples collected over 7 d period as well as CO2 samples collected over a 4 d period were analysed for the 14C. At termination caracasses from the animals administered NP-14C TP-9 and isolated ethylene 14C oxide TP-9 fractions was also analysed for 14C.
Within 7 days, the rat excreted both 14C-NP and NP-14C TP-9 as 20% in urine and 78% in faeces. However, there was no excretion in CO2when analysed over a 4 d period. Regarding the isolated ethylene 14C oxide TP-9 fractions, the 12- and 15-mole adducts were excreted to a greater extent in the feces than the 7- and 10-mole adducts and the reverse situation occurred in urine.
The major urinary metabolites analysed by ion exchange chromatography were found to be mono- and dicarboxylic acids of polyethylene glycol and the glucuronic acid conjugates of nonylphenol.
Under the condition of the study, the rat excreted both 14C-NP and NP-14C TP-9 as 20% in urine and 78% in feces and none in CO2 indicating an oral absorption of about 20%. Further, the 12- and 15-mole adducts of isolated ethylene 14C oxide TP-9 fractions were excreted to a greater extent in the feces than the 7- and 10-mole adducts and the reverse situation occurred in urine (Knaak et al., 1966).
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