4-Nonylphenol, ethoxylated

Endpoint summary

Description of key information

Short-term toxicity to aquatic invertebrates

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3). Effect concentration i.e EC50 value was estimated to be 1.43 mg/l for Daphnia magna for 24 hrs duration. It was concluded that the 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) was likely to be toxic to aquatic invertebrates, hence it can be considered to be classified as per the CLP classification criteria for aquatic environment.

Toxicity to aquatic algae and cyanobacteria

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, the toxicity to algae was predicted for 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3). Effect concentration i.e EC50 value was estimated to be 4.29 mg/l for Daphnia magna for 72 hrs duration. It was concluded that the 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) was likely to be toxic to algae, hence it can be considered to be classified as per the CLP classification criteria for aquatic environment.

Additional information

Short-term toxicity to aquatic invertebrates

Four studies including predicted data from validated tools and experimental data from peer reviewedjournal and authorative database for short term aquatic invertebrate’s endpoint of test chemical 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:

 

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the sixclosest read across substances, which indicate the short term toxicity on aquatic invertebrates was predicted for 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) and the Effect concentration i.e EC50 value was estimated to be 1.43 mg/l for Daphnia magna for 48 hrs duration.

 

Similar prediction by Danish (Q)SAR Database, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured program suggest the LC50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of Danish (Q)SAR Database, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 2.40 mg/l for4-Nonylphenol, ethoxylatedin 48 hrs.

 

Above both predicted results of target assist by experimental result of read across chemical 4-Nonylphenol, ethoxylated (Cas no. 9016-45-9) from peer reviewed journal Environmental Toxicology and Chemistry 2821-2829, 2001 which suggest the 48 h toxicity test of test chemical Nonylphenol, ethoxylated (Cas no 9016-45-9) with Daphnia magna were conducted in accordance with the recommended procedure outlined in U.S. EPA (2002). In experiment the Effective concentration to 50% of test organisms (EC50) on the basis of immobility effect was observed to be 2.8 mg/l 48 hrs exposure period for test chemical 4-Nonylphenol, ethoxylated (Cas no9016-45-9).

 

Another supporting study for read acrossDodecan-1-ol, ethoxylated(Cas no.9002-92-0) from peer reviewed journalEnvironmental Technology, 11(12): 1143-1146, 1990indicates short term toxicity to aquatic invertebrates was performed inGammarus italicusfor 24 hrs. Test in fresh water media with static condition. During the experiment, the EC50 value forDodecan-1-ol, ethoxylated(Cas no.9002-92-0) was determined to be 9.45 mg/l on the basis of mortality effect.

 

Thus based on the all available effect concentrations which is in the range of 1.43 mg/l to 9.45 mg/l for target and read across chemicals which come to the conclusion that test substance 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3)was likely to be non toxic to aquatic invertebrates as it not exceed the classification criteria, hence it can be considered to be not classified as per the CLP regulation.

Toxicity to aquatic algae and cyanobacteria

Two studies including predicted data from validated tools and experimental data from secondary source

for toxicity to aquatic algae endpoint of test chemical4-Nonylphenol, ethoxylated (Cas no. 26027-38-3) with relevant read across which is close to target using log Kow as primary descriptor were

summarised as follows:

 

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five

closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substance 4-Nonylphenol, ethoxylated (Cas no. 26027-38-3). EC50 value was estimated to be 4.29 mg/l for Pseudokirchneriella subcapitata for 72 h duration.

Predicted result for target supported by experimental data of read across chemical4-Nonylphenol, ethoxylated (Cas no. 26027-38-3)from robust summary of the IUCLID DATASET,ICI Internal Report BL4737/B1993 method the effect concentation (EC50) of substance4-Nonylphenol, ethoxylated (Cas no. 26027-38-3)in test speciesSkeletonema costatumwas observed to be2.5 mg/l  on the basis of Growth Rate effect for 72 hrs exposure period.

 

Thus based on the effect concentrations which is in the range 2.5 mg/l to 4.29 give the conclusion that test substance4-Nonylphenol, ethoxylated (Cas no. 26027-38-3)was likely to be non toxic to aquatic algae at environmentally relevant concentrations and can be considered to be not classified as per the CLP classification criteria.