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EC number: 500-045-0 | CAS number: 26027-38-3 1 - 2.5 moles ethoxylated
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from HSDB database.
Data source
Reference
- Reference Type:
- other: Authoritative database.
- Title:
- Determination of Acute oral toxicity.
- Author:
- U.S. National Library of Medicine, National Institutes of Health, Health & Human Services
- Year:
- 2 017
- Bibliographic source:
- HSDB, U.S. National Library of Medicine, National Institutes of Health, Health & Human Services, 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity in rats was perfromed using 2-Butoxyethanol.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-butoxyethanol
- EC Number:
- 203-905-0
- EC Name:
- 2-butoxyethanol
- Cas Number:
- 111-76-2
- Molecular formula:
- C6H14O2
- IUPAC Name:
- 2-Butoxyethanol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report):2-Butoxyethanol (Ethylene glycol monobutyl ether)
- Molecular formula: C6H14O2
- Molecular weight: 118.175 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):2-Butoxyethanol (Ethylene glycol monobutyl ether)
- Molecular formula: C6H14O2
- Molecular weight: 118.175 g/mol
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Not specified
- Doses:
- 670, 1310, 2560 and 5000 mg/kg
- No. of animals per sex per dose:
- 10 male rats in 4 group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and gross pathology was observed
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 590 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 110 - < 2 270
- Remarks on result:
- other: 50 % mortality was observed
- Mortality:
- Mortality was observed in 3 rats at the 1310 mg/kg dose level, 8 rats at the 2560 mg/kg dose level and all rats at the 5000 mg/kg dose level.
- Clinical signs:
- other: Piloerection and lethargy was observed for 1310, 2560 mg/kg, flaccidity at the 2560 mg/kg and ataxia at the 5000 mg/kg concentrations.
- Gross pathology:
- Dark liver and kidney was observed in 3 rats, and enlarged kidney in 4 rats at the 1310 mg/kg dose level along with red intestine in 1, blood in the bladder in all rats at the 2560 mg/kg dose level blood in the bladder in all rats at the 5000 mg/kg dose level.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD 50 value for acute oral toxicity for 2-Butoxyethanol (111-76-2) was considered to be 1,590 mg/kg for rats.
- Executive summary:
Acute oral toxicity to albino rats (wistar strain) was observed for 2-Butoxyethanol (111-76-2) in 4 groups of 10 male albino rats. The test concentration of 670, 1310, 2560 and 5000 mg/kg was used in 4 groups of 10 male albino rats. Mortality was observed in 3 rats at the 1310 mg/kg dose level, 8 rats at the 2560 mg/kg dose level and all rats at the 5000 mg/kg dose level. Piloerection and lethargy was observed for 1310, 2560 mg/kg,flaccidity at the 2560 mg/kg and ataxia at the 5000 mg/kg concentrations. Dark liver and kidney was observed in 3 rats, and enlarged kidney in 4 rats at the 1310 mg/kg dose level along with red intestine in 1, blood in the bladder in all rats at the 2560 mg/kg dose level blood in the bladder in all rats at the 5000 mg/kg dose level.
On the basis of these observation, the LD 50 value for acute oral toxicity for 2-Butoxyethanol (111-76-2) was considered to be 1,590 mg/kg for rats.Based on the value, 2-Butoxyethanol (111-76-2) was considered to be toxic to rats and can be classified in "acute category 4" as per the CLP regulations.
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