Registration Dossier
Registration Dossier
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EC number: 212-595-6 | CAS number: 830-13-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
- Principles of method if other than guideline:
- Acute oral toxicity "Farbenfabrik Bayer AG"
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclododecanone
- EC Number:
- 212-595-6
- EC Name:
- Cyclododecanone
- Cas Number:
- 830-13-7
- Molecular formula:
- C12H22O
- IUPAC Name:
- cyclododecanone
- Details on test material:
- Cyclododecanone of Hüls AG as produced in 1964, "chemically pure"
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no further information
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: acetone + vegetable oil (1:10)
- Details on oral exposure:
- ADMINISTRATION:
- Doses per time period: single dose (gavage)
- Volume administered or concentration: 5 ml/kg bw - Doses:
- 1000; 2000; 2500 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Post dose observation period: 7 days
- Statistics:
- no statistical analysis was performed
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Mortality:
- MORTALITY: no deaths at any dose
- Clinical signs:
- CLINICAL SIGNS: no animal of 1000 mg/kg bw group
all animals of 2000 and 2500 mg/kg bw groups: labored respiration, spasticity and impairment of general condition, beginning 1-3 hours after
treatment and fading within 2 days - Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
DOSE [mg/kg bw] MORTALITY/CLINICAL SIGNS/ANIMALS PER DO
------------------------------------------------------------------------
1000 0/0/10
2000 0/10/10
2500 0/10/10
Applicant's summary and conclusion
- Conclusions:
- Based on the results of the study the substance cyclododecanone showed low acute oral toxicity in rats.
- Executive summary:
An oral acute toxicity test was conducted with cyclododecanone in rats. The LD50 is greater than 2500 mg/kg bw. Based on the results of the study the substance cyclododecanone showed low acute oral toxicity in rats.
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