Registration Dossier
Registration Dossier
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EC number: 212-595-6 | CAS number: 830-13-7
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-04-21 to 1989-05-19
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
- Principles of method if other than guideline:
- Method: BODIS Test (ISO 10708, in preparation)
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclododecanone
- EC Number:
- 212-595-6
- EC Name:
- Cyclododecanone
- Cas Number:
- 830-13-7
- Molecular formula:
- C12H22O
- IUPAC Name:
- cyclododecanone
- Details on test material:
- Test substance: Cyclododecanone of Hüls AG, no further details
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- INOCULUM/TEST ORGANISM
- Type of sludge: 3.6 g dry weight/l - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 47.8 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST SYSTEM
- Culturing apparatus: 300 ml precision glass bottles
- Number of culture flasks per concentration: 3
- Measuring equipment: oxygen electrode
- Closed vessels used: yes
METHOD OF PREPARATION OF TEST SOLUTION
- Addition of test substance in acetone 24 hours prior to begin of test
TEST CONDITIONS
- Test temperature: 20 °C
ANALYTICAL PARAMETER: dissolved oxygen
Reference substance
- Reference substance:
- diethylene glycol
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 93
- Sampling time:
- 28 d
- Details on results:
- Kinetic of test substance (in %):
= 47 after 7 day(s)
= 73 after 14 day(s)
= 84 after 21 day(s)
Degradation products: not measured
BOD5 / COD results
- Results with reference substance:
- Kinetic of reference substance (in %):
= 81 after 14 day(s)
= 99 after 21 day(s)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test substance was found to be readily biodegradable.
- Executive summary:
The ultimate biodegradability of cyclododecanone was tested in the BODIS test (Two Phase Closed-Bottle test) according to the draft ISO guideline 10708 by Hüls AG (1989). The test media were inoculated with activated sludge and the oxygen consumption was monitored at weekly intervals over a period of 28 days. The test substance was observed to be readily biodegradable (93% degradation within 28 days).
The study was assessed as "reliable with restrictions".
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