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EC number: 203-721-0 | CAS number: 109-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrolysis
The half-life and alkaline hydrolysis rate constant of the test chemical was determined at a temperature of 25°C (from handbook, authoritative databases and secondary source). The alkaline hydrolysis rate constant of test chemical was determined to be 25.7L/mol-sec with a corresponding half-lives of 3.1 days and 7.5 hr at pH 7 and 8, and temperature of 25°C, respectively.The hydrolysis products of test chemical were formic acid and ethanol, respectively. Based on the half-life values, it is concluded that the test chemical undergoes moderate to slow hydrolysis in water.
Additional information
Hydrolysis
Experimental study and various predicted data of the test chemical were reviewed for the hydrolysis end point which are summarized as below:
In an experimental key study from handbook, authoritative databases and secondary source,the half-life and alkaline hydrolysis rate constant of the test chemical was determined at a temperature of 25°C. The alkaline hydrolysis rate constant of test chemical was determined to be 25.7L/mol-sec with a corresponding half-lives of 3.1 days and 7.5 hr at pH 7 and 8, and temperature of 25°C, respectively. The hydrolysis products of test chemical were formic acid and ethanol, respectively. Based on the half-life values, it is concluded that the test chemical undergoes moderate to slow hydrolysis in water.
In an another study (E. Rorije et. al., 1997), hydrolysis half-life value of test chemical was estimated using the HYDROWIN model. The models have been applied are Quantitative Structure-Activity Relationships. This model yields the second order alkaline hydrolysis reaction rate constant of chemical at pH 7.0. To arrive at an environmental half-life, this reaction rate constant should be multiplied by the concentration of hydroxyl ions in water. The hydrolysis half-live value of test chemical was determined to be 6.34 days at pH 7, respectively. The hydrolysis products of test chemical were formic acid and ethanol, respectively. Based on the half-life value, it is concluded that the test chemical undergoes slow hydrolysis in water.
HYDROWIN v2.00 program of Estimation Programs Interface prediction model was used to predict the hydrolysis half-life of test chemical (2018). The estimated half-life of test chemical was determined to be 5.411 days at pH 7.0 and 12.987 hrs at pH 8.0 (at 25ᵒC) respectively with a hydrolysis rate constant of 14.83 L/mol-sec. Thus, based on the half-life value, it indicates that test chemical undergoes moderate to slow hydrolysis in water.
On the basis of the above results of test chemical(fromhandbook, authoritative databases and secondary source,2017), it can be concluded that the hydrolysis half-life value of test chemical ranges from 7.5 hr to 6.34 days, indicating that the test chemical undergoes moderate to slow hydrolysis in water.
Hydrolysis endpoint can also be considered for waiver as per in accordance with column 2 of Annex VIII of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable in water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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